Anti-Glucagon-Cell and Anti-Adrenal-Medullary-Cell Antibodies in Islet-Cell-Autoantibody-Positive Diabetic Children

K. Schopfer, L. Matter, R. Tenschert, S. Bauer, K. Zuppinger, Neil H. White, Donald A. Skor, Philip E. Cryer, Julio V. Santiago

Research output: Contribution to journalLetterpeer-review

19 Scopus citations


To the Editor: Insulin-dependent diabetic patients have a high prevalence of circulating islet-cell autoantibodies at the time of diagnosis.1 It has become evident from recent studies that these autoantibodies reflect a heterogeneous group of antibodies reacting with different cells within the islets and with various cytoplasmic and membrane epitopes on single islet cells.2 3 4 We report here our recent finding of antibodies reacting with cytoplasmic structures of adrenal medullary cells in a proportion of diabetic patients positive for islet-cell autoantibodies. Since March 1981 all newly diagnosed insulin-dependent diabetic children who were positive for islet-cell autoantibodies were studied (19 female and 24.

Original languageEnglish
Pages (from-to)1536-1537
Number of pages2
JournalNew England Journal of Medicine
Issue number23
StatePublished - Jun 7 1984


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