Anti-CD30 antibodies for Hodgkin lymphoma

Kelley V. Foyil, Nancy L. Bartlett

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

Treatment of refractory or relapsed classical Hodgkin lymphoma (HL) remains challenging, but targeted immunotherapy has recently emerged as a potential treatment option for these patients. Although first-generation monoclonal anti-CD30 antibodies proved disappointing, current efforts to modify anti-CD30 antibodies to improve binding of effector cells and enhance activity appears more promising, as does the development of novel antibody-drug conjugates (ADCs). ADCs offer the potential to deliver potent therapies with minimal toxicity. One highly active ADC, brentuximab vedotin (SGN-35), combines an anti-CD30 monoclonal antibody and the antitubulin agent monomethyl auristatin E. Initial phase 1 studies of brentuximab vedotin showed a 52% overall response rate in relapsed HL, with minimal toxicity. This article highlights the development of anti-CD30 antibodies and ADCs for relapsed or refractory classical HL.

Original languageEnglish
Pages (from-to)140-147
Number of pages8
JournalCurrent Hematologic Malignancy Reports
Volume5
Issue number3
DOIs
StatePublished - Jul 2010

Keywords

  • Anti-CD30 antibodies
  • Brentuximab vedotin
  • Hodgkin lymphoma
  • SGN-35

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