Anthrax toxins inhibit neutrophil signaling pathways in brain endothelium and contribute to the pathogenesis of meningitis

Keyphrases

• Neutrophils 100%
• Signaling Pathway 100%
• Blood-brain Barrier 100%
• Meningitis 100%
• Brain Endothelium 100%
• Anthrax Toxin 100%
• Anthracis 80%
• Anthrax 60%
• Human Brain Microvascular Endothelial Cells (HBMEC) 60%
• Innate Immune Response 20%
• Mouse Model 20%
• Effective Treatment 20%
• Central Nervous System 20%
• Interleukin-8 20%
• Cell Layer 20%
• Cell Response 20%
• Disease Pathogenesis 20%
• Transcriptional Profiling 20%
• Treatment Strategy 20%
• Systemic Infection 20%
• Active Role 20%
• In Vivo Assay 20%
• Pathogenic Mechanism 20%
• Infection Site 20%
• Bacillus 20%
• Neutrophil Recruitment 20%
• Neutrophil Chemotaxis 20%
• Disease Development 20%
• Neurological Complications 20%
• Quantitative RT-PCR 20%
• In Vitro Blood-brain Barrier Model 20%
• PCR-ELISA 20%
• Bacillus Anthracis 20%
• CXCL2 20%
• CXCL1 20%
• Brain Autopsy 20%
• Meningeal 20%
• Physical Barrier 20%
• Chemokine Production 20%
• Vegetative Bacteria 20%
• Innate Defence Response 20%
• Sterne 20%

Immunology and Microbiology

• Meningitis 100%
• Blood Brain Barrier 100%
• Neutrophil 100%
• Mouse Model 16%
• Chemoattractant 16%
• Downregulation 16%
• Infectious Agent 16%
• Chemokine 16%
• Central Nervous System 16%
• Quantitative Reverse Transcription Polymerase Chain Reaction 16%
• ELISA 16%
• Innate Immune System 16%
• CXCL1 16%
• CXCL2 16%
• Bacillus Anthracis 16%
• Gene Expression Assay 16%
• Interleukin 8 16%

Biochemistry, Genetics and Molecular Biology

• Blood Brain Barrier 100%
• Anthrax Toxin 100%
• Downregulation 16%
• Mouse Model 16%
• Gene Expression Profiling 16%
• Infectious Agent 16%
• Chemokine 16%
• Innate Immunity 16%
• Quantitative Reverse Transcription Polymerase Chain Reaction 16%
• Interleukin 8 16%
• CXCL2 16%
• CXCL1 16%
• Defense Response 16%
• Bacillus Anthracis 16%