TY - JOUR
T1 - Anthracycline Cardiotoxicity
T2 - It Is Possible to Teach an Old Dog Some New Tricks
AU - Alvarez-Cardona, Jose
AU - Lenihan, Daniel J.
PY - 2019/11
Y1 - 2019/11
N2 - Anthracyclines have proved to be one of the most effective chemotherapeutic agents in the treatment of numerous solid tumors and hematologic malignancies in both adult and pediatric patients. Their clinical benefit, however, is sometimes hampered by the development of cardiotoxicity, a process that still remains elusive despite decades of investigation. It has been postulated that anthracycline-induced cardiotoxicity is mediated in part by reactive oxygen species and redox cycling. This article reviews anthracycline cardiotoxicity in terms of historical significance, epidemiology, current detection strategies, prevention strategies, and patient care after anthracycline-based chemotherapy.
AB - Anthracyclines have proved to be one of the most effective chemotherapeutic agents in the treatment of numerous solid tumors and hematologic malignancies in both adult and pediatric patients. Their clinical benefit, however, is sometimes hampered by the development of cardiotoxicity, a process that still remains elusive despite decades of investigation. It has been postulated that anthracycline-induced cardiotoxicity is mediated in part by reactive oxygen species and redox cycling. This article reviews anthracycline cardiotoxicity in terms of historical significance, epidemiology, current detection strategies, prevention strategies, and patient care after anthracycline-based chemotherapy.
KW - Anthracycline cardiotoxicity
KW - Cardioprotection
KW - Chemotherapeutic agents
KW - Left ventricular ejection fraction (LVEF)
UR - http://www.scopus.com/inward/record.url?scp=85072773754&partnerID=8YFLogxK
U2 - 10.1016/j.ccl.2019.08.001
DO - 10.1016/j.ccl.2019.08.001
M3 - Review article
C2 - 31587778
AN - SCOPUS:85072773754
SN - 0733-8651
VL - 37
SP - 355
EP - 363
JO - Cardiology clinics
JF - Cardiology clinics
IS - 4
ER -