Anterior polar cataract: Clinical spectrum and genetic linkage in a single family

Alexander Ionides, Vanita Berry, Donna Mackay, Alan Shiels, Shomi Bhattacharya, Anthony Moore

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Anterior polar cataract can occur as a sporadic finding, in association with other ocular abnormalities or as an inherited, autosomal dominant disorder. We have demonstrated linkage in a family with autosomal dominant anterior polar cataract to the short arm of chromosome 17, locating the gene to the region 17p12-13. All affected members of this large family had an opacity at the anterior pole of the lens that varied only in size and the effect on visual acuity. Anterior polar cataract is thought to have a minimal effect on visual acuity although in the affected members of this family there was a high incidence of unilateral amblyopia.

Original languageEnglish
Pages (from-to)224-226
Number of pages3
JournalEye
Volume12
Issue number2
DOIs
StatePublished - Apr 1998
Externally publishedYes

Keywords

  • Anterior polar
  • Autosomal dominant
  • Cataract
  • Linkage
  • Phenotype

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    Ionides, A., Berry, V., Mackay, D., Shiels, A., Bhattacharya, S., & Moore, A. (1998). Anterior polar cataract: Clinical spectrum and genetic linkage in a single family. Eye, 12(2), 224-226. https://doi.org/10.1038/eye.1998.53