TY - JOUR
T1 - Antenatal steroids and intraventricular hemorrhage after premature rupture of membranes at 24-28 weeks' gestation
AU - Chen, Bruce
AU - Basil, Jack B.
AU - Schefft, Georgia L.
AU - Cole, F. Sessions
AU - Sadovsky, Yoel
PY - 1997/3
Y1 - 1997/3
N2 - To determine whether antenatal corticosteroid administration after midtrimester premature rupture of membranes (PROM) reduces the incidence or severity of neonatal intraventricular hemorrhage, we identified a cohort of infants delivered between 24 to 28 weeks gestation (n=75) by mothers with PROM. Information was obtained from a computerized database (n=3716) of all newborns admitted to the neonatal intensive care unit at a single medical center from 1991 to 1996. We reviewed records of each mother-infant pair to determine antenatal corticosteroid administration, presence, and severity of neonatal intraventricular hemorrhage, and frequency of infectious complications. Using a logistic regression model, antenatal corticosteroid administration was associated with a significantly reduced risk of severe (grade 3-4) intraventricular hemorrhage (0.1 odds ratio, 0.006-0.57, 95% confidence interval), but not a reduced incidence of intraventricular hemorrhage (grade 1-4, 0.4 odds ratio, 0.12-1.05, 95% confidence interval).
AB - To determine whether antenatal corticosteroid administration after midtrimester premature rupture of membranes (PROM) reduces the incidence or severity of neonatal intraventricular hemorrhage, we identified a cohort of infants delivered between 24 to 28 weeks gestation (n=75) by mothers with PROM. Information was obtained from a computerized database (n=3716) of all newborns admitted to the neonatal intensive care unit at a single medical center from 1991 to 1996. We reviewed records of each mother-infant pair to determine antenatal corticosteroid administration, presence, and severity of neonatal intraventricular hemorrhage, and frequency of infectious complications. Using a logistic regression model, antenatal corticosteroid administration was associated with a significantly reduced risk of severe (grade 3-4) intraventricular hemorrhage (0.1 odds ratio, 0.006-0.57, 95% confidence interval), but not a reduced incidence of intraventricular hemorrhage (grade 1-4, 0.4 odds ratio, 0.12-1.05, 95% confidence interval).
KW - Corticosteroids
KW - intraventricular hemorrhage
KW - premature rupture of membranes
UR - http://www.scopus.com/inward/record.url?scp=0031000727&partnerID=8YFLogxK
U2 - 10.1055/s-2007-994121
DO - 10.1055/s-2007-994121
M3 - Article
C2 - 9259922
AN - SCOPUS:0031000727
VL - 14
SP - 171
EP - 176
JO - American Journal of Perinatology
JF - American Journal of Perinatology
SN - 0735-1631
IS - 3
ER -