Ante- and postmortem tau in autosomal dominant and late-onset Alzheimer’s disease

for the Dominantly Inherited Alzheimer Network (DIAN) and for the Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU)

Research output: Contribution to journalArticlepeer-review

Abstract

Antemortem tau positron emission tomography imaging suggests elevated tau pathology in autosomal dominant versus late-onset Alzheimer’s disease at equivalent clinical stages, but does not implicate the specific tau pathologies responsible. Here we made stereological measurements of tau neurofibrillary tangles, neuritic plaques, and neuropil threads and found compared to late-onset Alzheimer’s disease, autosomal dominant Alzheimer’s disease showed even greater tangle and thread burdens. Regional tau burden resembled that observed in tau imaging of a separate cohort at earlier clinical stages. Finally, our results suggest tau imaging measures total tau burden in Alzheimer’s disease, composed predominantly of tangle and thread pathology.

Original languageEnglish
Pages (from-to)2475-2480
Number of pages6
JournalAnnals of Clinical and Translational Neurology
Volume7
Issue number12
DOIs
StatePublished - Dec 2020

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