Antagonistic effects of phorbol esters on lymphocyte activation. Evidence that protein kinase C provides an early signal associated with lytic function

J. H. Russell, D. E. McCulley, A. S. Taylor

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

There is increasing evidence that protein kinase C plays a role in the transduction of an activation signal in lymphocytes. The bulk of this evidence is based on pharmacological experiments involving the tumor promoter phorbol myristate acetate (PMA) as a protein kinase C agonist. However, in cytotoxic T lymphocytes, PMA has been shown to both stimulate and inhibt lytic function. By examining the effects of a series of phorbol esters on protein kinase C activity in lymphocytes, we will demonstrate that these antagonistic effects of PMA on cytotoxic T lymphocyte function are related to multiple effects of PMA on protein kinase C activity.

Original languageEnglish
Pages (from-to)12643-12648
Number of pages6
JournalJournal of Biological Chemistry
Volume261
Issue number27
StatePublished - Dec 1 1986

Fingerprint Dive into the research topics of 'Antagonistic effects of phorbol esters on lymphocyte activation. Evidence that protein kinase C provides an early signal associated with lytic function'. Together they form a unique fingerprint.

  • Cite this