Anodic Cyclizations and Umpolung Reactions Involving Imines

Zach Medcalf, Essence G. Redd, Jaemyeong Oh, Chang Ji, Kevin D. Moeller

Research output: Contribution to journalArticlepeer-review


Recent discoveries that anodic cyclization reactions rely heavily on the success of a second electron oxidation downstream of the cyclization suggest that this second electron oxidation step can be used to channel a reaction down new synthetic pathways. Here we describe one such application that reverses the normal reactivity of an imine group and sets the stage for the asymmetric synthesis of cyclic amines by anodic cyclization.

Original languageEnglish
Pages (from-to)4135-4139
Number of pages5
JournalOrganic Letters
Issue number22
StatePublished - Jun 9 2023


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