Anodic cyclization reactions and the synthesis of (-)-crobarbatic acid

Hai Chao Xu, John D. Brandt, Kevin D. Moeller

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

A synthesis of (-)-crobarbatic acid is reported along with the first use of a vinyl-substituted ketene dithioacetal as a coupling partner for an anodic cyclization reaction. The use of the vinyl-substituted ketene dithioacetal enables the construction of a cyclic product having a tetrasubstituted carbon with a relative stereochemistry opposite to that originally obtained from the cyclization.

Original languageEnglish
Pages (from-to)3868-3871
Number of pages4
JournalTetrahedron Letters
Volume49
Issue number24
DOIs
StatePublished - Jun 9 2008

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