TY - JOUR
T1 - Anion transport in liposomes responds to variations in the anchor chains and the fourth amino acid of heptapeptide ion channels
AU - Ferdani, Riccardo
AU - Pajewski, Robert
AU - Djedovič, Natasha
AU - Pajewska, Jolanta
AU - Schlesinger, Paul H.
AU - Gokel, George W.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2005/5
Y1 - 2005/5
N2 - Seven heptapeptide derivatives have been prepared. The peptide structure is (Gly)3Xxx(Gly)3 in which Xxx stands for a variable amino acid. The amino acid variations include azetidine carboxylic acid, pipecolic acid, meta-aminobenzoic acid, proline, and leucine. All seven compounds have a C-terminal benzyl group. In all cases, the heptapeptide's N-terminus was linked to diglycolic acid and a dialkylamine. In five cases, the N-terminal group was didecylamine and in two cases, N-ethyl-N-decyl. Chloride and carboxyfluorescein release from phospholipid vesicles was studied with the result that C 10H21N(C2H5)COCH2OCH 2CO-NH-(Gly)3Leu(Gly)3-OCH2Ph was the most active. Hill analysis showed that this compound involves pore formation by four monomer units rather than two, as previously found for other members of this family.
AB - Seven heptapeptide derivatives have been prepared. The peptide structure is (Gly)3Xxx(Gly)3 in which Xxx stands for a variable amino acid. The amino acid variations include azetidine carboxylic acid, pipecolic acid, meta-aminobenzoic acid, proline, and leucine. All seven compounds have a C-terminal benzyl group. In all cases, the heptapeptide's N-terminus was linked to diglycolic acid and a dialkylamine. In five cases, the N-terminal group was didecylamine and in two cases, N-ethyl-N-decyl. Chloride and carboxyfluorescein release from phospholipid vesicles was studied with the result that C 10H21N(C2H5)COCH2OCH 2CO-NH-(Gly)3Leu(Gly)3-OCH2Ph was the most active. Hill analysis showed that this compound involves pore formation by four monomer units rather than two, as previously found for other members of this family.
UR - http://www.scopus.com/inward/record.url?scp=19544381884&partnerID=8YFLogxK
U2 - 10.1039/b417808b
DO - 10.1039/b417808b
M3 - Article
C2 - 19169373
AN - SCOPUS:19544381884
VL - 29
SP - 673
EP - 680
JO - New Journal of Chemistry
JF - New Journal of Chemistry
SN - 1144-0546
IS - 5
ER -