Animal models of meniscal injury in post-traumatic arthritis

Chia Lung Wu; Dianne Little

doi:10.1007/978-1-4899-7606-2_5

Animal models of meniscal injury in post-traumatic arthritis

Chia Lung Wu, Dianne Little

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

3 Scopus citations

Abstract

The meniscus plays a significant role in maintenance of joint stability and congruence. Injuries to the meniscus often lead to post-traumatic arthritis and joint degeneration. To investigate development of post-traumatic OA and evaluate the chondroprotective effects of the meniscus, various animal models of meniscal injury have been developed. However, selection of an appropriate animal model is crucial in designing a study with translational relevance due to the diverse range of possible m eniscal injury patterns, and anatomical differences between animals and humans. This chapter outlines considerations for selection of a meniscal injury model, describes the injury models that have been investigated, and discusses confounding variables and outcome measures for evaluation of structural and functional changes in the joint following meniscal injury.

Original language	English
Title of host publication	Post-Traumatic Arthritis
Subtitle of host publication	Pathogenesis, Diagnosis and Management
Publisher	Springer US
Pages	41-62
Number of pages	22
ISBN (Electronic)	9781489976062
ISBN (Print)	9781489976055
DOIs	https://doi.org/10.1007/978-1-4899-7606-2_5
State	Published - Jan 1 2015
Externally published	Yes

Keywords

Femur
Fibrocartilage
Fibrochondrocyte
OA
Synovitis
Tibia

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10.1007/978-1-4899-7606-2_5

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abstract = "The meniscus plays a significant role in maintenance of joint stability and congruence. Injuries to the meniscus often lead to post-traumatic arthritis and joint degeneration. To investigate development of post-traumatic OA and evaluate the chondroprotective effects of the meniscus, various animal models of meniscal injury have been developed. However, selection of an appropriate animal model is crucial in designing a study with translational relevance due to the diverse range of possible m eniscal injury patterns, and anatomical differences between animals and humans. This chapter outlines considerations for selection of a meniscal injury model, describes the injury models that have been investigated, and discusses confounding variables and outcome measures for evaluation of structural and functional changes in the joint following meniscal injury.",

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KW - Synovitis

KW - Tibia

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Animal models of meniscal injury in post-traumatic arthritis

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Keywords

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