Animal models of altered glucocorticoid signaling

Charles Harris

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


In this chapter we will review genetically engineered mice with alterations in glucocorticoid signaling. Most of the mice involve direct alterations to the glucocorticoid receptor locus, but we will touch briefl y on other relevant models including 11-β-HSD transgenics which alter tissue levels of ligand as well as mice with glucocorticoid excess. Of course, the number of mice with mutations in genes such as GR targets and transcriptional coregulators is beyond the scope of this chapter.

Original languageEnglish
Pages (from-to)337-352
Number of pages16
JournalAdvances in Experimental Medicine and Biology
StatePublished - 2015


  • 11-β-HSD transgenics
  • Altered glucocorticoid signaling
  • Animal models
  • GR-null mice
  • Hypomorphs
  • Tissue specifi c KO
  • Tissue-specifi c transgenics


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