TY - JOUR
T1 - Animal models for human T-lymphotropic virus type 1 (HTLV-1) infection and transformation
AU - Lairmore, Michael D.
AU - Silverman, Lee
AU - Ratner, Lee
N1 - Funding Information:
This work was supported by National Institute of Health grants RR-14324 and CA-100730 awarded to Dr Michael Lairmore and CA-70529 and CA-09338 awarded through the Ohio State University Comprehensive Cancer Center.
PY - 2005/9/5
Y1 - 2005/9/5
N2 - Over the past 25 years, animal models of human T-lymphotropic virus type 1 (HTLV-1) infection and transformation have provided critical knowledge about viral and host factors in adult T-cell leukemia/lymphoma (ATL). The virus consistently infects rabbits, some non-human primates, and to a lesser extent rats. In addition to providing fundamental concepts in viral transmission and immune responses against HTLV-1 infection, these models have provided new information about the role of viral proteins in carcinogenesis. Mice and rats, in particular immunodeficient strains, are useful models to assess immunologic parameters mediating tumor outgrowth and therapeutic invention strategies against lymphoma. Genetically altered mice including both transgenic and knockout mice offer important models to test the role of specific viral and host genes in the development of HTLV-1-associated lymphoma. Novel approaches in genetic manipulation of both HTLV-1 and animal models are available to address the complex questions that remain about viral-mediated mechanisms of cell transformation and disease. Current progress in the understanding of the molecular events of HTLV-1 infection and transformation suggests that answers to these questions are approachable using animal models of HTLV-1-associated lymphoma.
AB - Over the past 25 years, animal models of human T-lymphotropic virus type 1 (HTLV-1) infection and transformation have provided critical knowledge about viral and host factors in adult T-cell leukemia/lymphoma (ATL). The virus consistently infects rabbits, some non-human primates, and to a lesser extent rats. In addition to providing fundamental concepts in viral transmission and immune responses against HTLV-1 infection, these models have provided new information about the role of viral proteins in carcinogenesis. Mice and rats, in particular immunodeficient strains, are useful models to assess immunologic parameters mediating tumor outgrowth and therapeutic invention strategies against lymphoma. Genetically altered mice including both transgenic and knockout mice offer important models to test the role of specific viral and host genes in the development of HTLV-1-associated lymphoma. Novel approaches in genetic manipulation of both HTLV-1 and animal models are available to address the complex questions that remain about viral-mediated mechanisms of cell transformation and disease. Current progress in the understanding of the molecular events of HTLV-1 infection and transformation suggests that answers to these questions are approachable using animal models of HTLV-1-associated lymphoma.
KW - Animal models
KW - HTLV-1
KW - Leukemia
KW - Lymphoma
UR - http://www.scopus.com/inward/record.url?scp=25444483891&partnerID=8YFLogxK
U2 - 10.1038/sj.onc.1208974
DO - 10.1038/sj.onc.1208974
M3 - Article
C2 - 16155607
AN - SCOPUS:25444483891
SN - 0950-9232
VL - 24
SP - 6005
EP - 6015
JO - Oncogene
JF - Oncogene
IS - 39
ER -