Angiotensin II and gene expression in the kidney

Saulo Klahr, Jeremiah Morrissey

Research output: Contribution to journalArticlepeer-review

123 Scopus citations

Abstract

Angiotensin II, a potent vasoconstrictor, has a key role in renal injury and in the progression of chronic renal disease of diverse causes. In vascular smooth muscle cells, angiotensin II modulates growth, which may lead to hypertrophy and also may inhibit mitogen-stimulated DNA synthesis. The effects of angiotensin II on responsive cells are mediated by two classes of receptors, AT-1 and AT-2. Information obtained in the last decade indicates that angiotensin II increases the production of several autocrine factors, including transforming growth factor β1 (TGF-β1), tumor necrosis factor-α (TNF-α), and platelet-derived growth factor A chain (PDGF). Angiotensin also increases the release of other growth factors such as endothelin, platelet- activating factor (PAF), and interleukin 6. In addition, it increases the 'activity' of nuclear factor-κB (NF-κB) and the synthesis of angiotensinogen. The emerging picture indicates that the actions of angiotensin II may be related to factors that are released or upregulated by angiotensin II, possibly through NF-κB activation. It appears likely that many of the effects of angiotensin II on renal disease may be mediated by TGF-β1, TNF-α, and changes in the activity of NF-κB. The use of ACE inhibitors or antagonists of AT-1 or AT-2 receptors in experimental animals decreases the levels of angiotensin II or limits its action, thereby interfering with the production and effects of the factors described.

Original languageEnglish
Pages (from-to)171-176
Number of pages6
JournalAmerican Journal of Kidney Diseases
Volume31
Issue number1
DOIs
StatePublished - Jan 1998

Keywords

  • Angiotensin II
  • Cytokines
  • Fibrosis
  • Transcription factors

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