Angiotensin I converting enzyme gene polymorphism and insulin resistance in patients with angina pectoris

Takanobu Takezako, Keijiro Saku, Bo Zhang, Jiafu Ou, Huai Bai, Kimiko Imai, Shiro Jimi, Kazuyuki Shirai, Kikuo Arakawa

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The association between insertion/deletion polymorphism of the angiotensin I converting enzyme (ACE) gene and insulin resistance (IR) was investigated in 64 consecutive patients (F/M: 11/53) with angina pectoris without clinically manifest diabetes mellitus who underwent diagnostic coronary angiography. The observed frequency distribution of ACE genotypes did not deviate from that predicted from the Hardy-Weinberg equilibrium in this group. Patients with the ACE-ID genotype had significantly lower IR, as assessed by an oral glucose tolerance test (OGTT) and by homeostatic model assessment (HOMA), compared to those with the ACE-II genotype, as assessed by a multiple comparison analysis. Patients were divided into two groups with low and high HOMA-IR, and the I allele was seen more frequently in the high HOMA-IR group than in the low HOMA-IR group (0.62 v 0.47, respectively, by ξ2 test, P < .05). Logistic regression analysis showed that the odds ratio for insulin resistance in patients with the II genotype, compared to those with the ID and DD genotypes (assuming that the I allele has a recessive effect), was 4.0 (95% confidence interval, 1.2 to 16.5; P = .037), after adjusting for the presence of significant coronary atherosclerosis. In conclusion, the D allele was not associated with higher insulin resistance in patients with angina pectoris; that is, patients with the ID and DD genotypes were associated with a significantly lower risk of insulin resistance, compared to those with the II genotype.

Original languageEnglish
Pages (from-to)291-297
Number of pages7
JournalAmerican Journal of Hypertension
Volume12
Issue number3
DOIs
StatePublished - Mar 1 1999
Externally publishedYes

Keywords

  • Angiotensin I converting enzyme gene
  • Genetics
  • Insertion/deletion polymorphism
  • Insulin resistance

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