TY - JOUR
T1 - Angiogenic factors in endometriosis
AU - Taylor, Robert N.
AU - Lebovic, Dan I.
AU - Mueller, Michael D.
PY - 2002
Y1 - 2002
N2 - Similar to tumor metastases, endometriotic implants require neovascularization to establish, grow, and invade. The peritoneal environment is ideally suited to provide a proangiogenic milieu. Nevertheless, endometriotic lesions are found only in a minority of reproductive-age women (∼10%) with retrograde menstruation. In this paper, we review the major cytokines, growth factors, steroid hormones, and eicosanoids responsible for angiogenesis in endometriosis. We postulate that interference with angiogenic principles expressed in the peritoneum may constitute novel therapeutic opportunities for the prevention, amelioration, or treatment of pelvic endometriosis.
AB - Similar to tumor metastases, endometriotic implants require neovascularization to establish, grow, and invade. The peritoneal environment is ideally suited to provide a proangiogenic milieu. Nevertheless, endometriotic lesions are found only in a minority of reproductive-age women (∼10%) with retrograde menstruation. In this paper, we review the major cytokines, growth factors, steroid hormones, and eicosanoids responsible for angiogenesis in endometriosis. We postulate that interference with angiogenic principles expressed in the peritoneum may constitute novel therapeutic opportunities for the prevention, amelioration, or treatment of pelvic endometriosis.
KW - Cytokines
KW - Estrogen receptors
KW - Neovascularization
KW - Vascular endothelial growth factor (VEGF)
UR - http://www.scopus.com/inward/record.url?scp=0036213759&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2002.tb02769.x
DO - 10.1111/j.1749-6632.2002.tb02769.x
M3 - Article
C2 - 11949968
AN - SCOPUS:0036213759
SN - 0077-8923
VL - 955
SP - 89
EP - 100
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
ER -