Angiogenesis in Nervous System Disorders

Gelareh Zadeh, Abhijit Guha, Mitchel S. Berger, Charles J. Hodge, Ralph G. Dacey, E. Sander Connolly, Murat Gunel

Research output: Contribution to journalReview article

57 Scopus citations

Abstract

ANGIOGENESIS IS A crucial requirement for embryonal development and new vessel formation during adult life. Various disease processes such as cancer, ischemia, vascular malformations, and inflammatory processes also depend on pathological angiogenesis. A better understanding of the complex and coordinated interactions among various angiogenic pathways involved in pathological angiogenesis is necessary to improve our therapeutic approaches to the various disease processes observed in the central nervous system. This review summarizes the current understanding of the role of principal angiogenic factors relevant to neurosurgical abnormalities.

Original languageEnglish
Pages (from-to)1362-1376
Number of pages15
JournalNeurosurgery
Volume53
Issue number6
DOIs
StatePublished - Dec 2003
Externally publishedYes

Keywords

  • Angiogenesis
  • Angiopoietins
  • Antiangiogenic therapy Central nervous system
  • Vascular endothelial growth factor, Vasculogenesis

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  • Cite this

    Zadeh, G., Guha, A., Berger, M. S., Hodge, C. J., Dacey, R. G., Connolly, E. S., & Gunel, M. (2003). Angiogenesis in Nervous System Disorders. Neurosurgery, 53(6), 1362-1376. https://doi.org/10.1227/01.NEU.0000093425.98136.31