@article{77c0d6503bf64bee90fe18f419e341e5,
title = "Angiogenesis in Nervous System Disorders",
abstract = "ANGIOGENESIS IS A crucial requirement for embryonal development and new vessel formation during adult life. Various disease processes such as cancer, ischemia, vascular malformations, and inflammatory processes also depend on pathological angiogenesis. A better understanding of the complex and coordinated interactions among various angiogenic pathways involved in pathological angiogenesis is necessary to improve our therapeutic approaches to the various disease processes observed in the central nervous system. This review summarizes the current understanding of the role of principal angiogenic factors relevant to neurosurgical abnormalities.",
keywords = "Angiogenesis, Angiopoietins, Antiangiogenic therapy Central nervous system, Vascular endothelial growth factor, Vasculogenesis",
author = "Gelareh Zadeh and Abhijit Guha and Berger, {Mitchel S.} and Hodge, {Charles J.} and Dacey, {Ralph G.} and Connolly, {E. Sander} and Murat Gunel",
note = "Funding Information: Declaration. This article was part of the submission towards NM{\textquoteright}s PhD (Health Sciences). Acknowledgements. The authors thank the hospital management and all healthcare workers at the study site for their assistance and support. The assistance of Dr Cathy Connolly with statistical guidance and interpretation is greatly appreciated. Author contributions. NM was responsible for the literature search, study design, data collection, data analysis and interpretation. All authors contributed equally to the analysis and write-up of the manuscript. Funding. NM was supported by University of KwaZulu-Natal School of Health Sciences for registration fees, seed funding was provided by the Medical Education Partnership Initiative (MEPI) Grant Implementation Science Traineeship Program funded by the US President{\textquoteright}s Emergency Plan for AIDS Relief (PEPFAR) through the Fogarty International Centre, National Institutes of Health (grant #D43TW00231), and a further grant was awarded by CAPRISA, MRC TB-HIV Pathogenesis and Treatment Research Unit, Durban, South Africa. Conflicts of interest. None.",
year = "2003",
month = dec,
doi = "10.1227/01.NEU.0000093425.98136.31",
language = "English",
volume = "53",
pages = "1362--1376",
journal = "Neurosurgery",
issn = "0148-396X",
number = "6",
}