Aneurysms Caused by Connective Tissue Abnormalities

Rebecca A. Sorber; James H. Black

doi:10.1016/B978-0-323-77557-1.00141-7

Aneurysms Caused by Connective Tissue Abnormalities

Rebecca A. Sorber
, James H. Black

Section of Vascular Surgery

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

A connective tissue disorder is a genetic disease in which the primary target is either collagen or elastin protein assembly, disruption of which leads to an inherent predisposition to degeneration, loss of structural integrity, and consequent aneurysm formation or spontaneous vascular dissection and rupture. These “heritable disorders of connective tissue” can have severe vascular manifestations and most commonly include Marfan syndrome, the vascular type of Ehlers-Danlos syndrome (EDS IV or vEDS), Loeys-Dietz syndrome (LDS), and familial thoracic aortic aneurysm and dissection (TAAD).

Original language	English
Title of host publication	Rutherford's Vascular Surgery and Endovascular Therapy, Tenth Edition
Subtitle of host publication	Volume 1-2
Publisher	Elsevier
Pages	1858-1876.e2
Volume	1-2
ISBN (Electronic)	9780323775571
ISBN (Print)	9780323775601
DOIs	https://doi.org/10.1016/B978-0-323-77557-1.00141-7
State	Published - Jan 1 2022

Keywords

connective tissue disorder
familial thoracic aortic aneurysm
genetic aortic disease
Loeys-Dietz syndrome
Marfan syndrome
vascular Ehlers-Danlos syndrome

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10.1016/B978-0-323-77557-1.00141-7

Cite this

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abstract = "A connective tissue disorder is a genetic disease in which the primary target is either collagen or elastin protein assembly, disruption of which leads to an inherent predisposition to degeneration, loss of structural integrity, and consequent aneurysm formation or spontaneous vascular dissection and rupture. These “heritable disorders of connective tissue” can have severe vascular manifestations and most commonly include Marfan syndrome, the vascular type of Ehlers-Danlos syndrome (EDS IV or vEDS), Loeys-Dietz syndrome (LDS), and familial thoracic aortic aneurysm and dissection (TAAD).",

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AU - Black, James H.

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N2 - A connective tissue disorder is a genetic disease in which the primary target is either collagen or elastin protein assembly, disruption of which leads to an inherent predisposition to degeneration, loss of structural integrity, and consequent aneurysm formation or spontaneous vascular dissection and rupture. These “heritable disorders of connective tissue” can have severe vascular manifestations and most commonly include Marfan syndrome, the vascular type of Ehlers-Danlos syndrome (EDS IV or vEDS), Loeys-Dietz syndrome (LDS), and familial thoracic aortic aneurysm and dissection (TAAD).

AB - A connective tissue disorder is a genetic disease in which the primary target is either collagen or elastin protein assembly, disruption of which leads to an inherent predisposition to degeneration, loss of structural integrity, and consequent aneurysm formation or spontaneous vascular dissection and rupture. These “heritable disorders of connective tissue” can have severe vascular manifestations and most commonly include Marfan syndrome, the vascular type of Ehlers-Danlos syndrome (EDS IV or vEDS), Loeys-Dietz syndrome (LDS), and familial thoracic aortic aneurysm and dissection (TAAD).

KW - connective tissue disorder

KW - familial thoracic aortic aneurysm

KW - genetic aortic disease

KW - Loeys-Dietz syndrome

KW - Marfan syndrome

KW - vascular Ehlers-Danlos syndrome

UR - https://www.scopus.com/pages/publications/85216397913

U2 - 10.1016/B978-0-323-77557-1.00141-7

DO - 10.1016/B978-0-323-77557-1.00141-7

M3 - Chapter

AN - SCOPUS:85216397913

SN - 9780323775601

VL - 1-2

SP - 1858-1876.e2

BT - Rutherford's Vascular Surgery and Endovascular Therapy, Tenth Edition

PB - Elsevier

ER -

Aneurysms Caused by Connective Tissue Abnormalities

Abstract

Keywords

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