TY - JOUR
T1 - Anellovirus Dynamics Are Associated with Primary Graft Dysfunction in Lung Transplantation
AU - Blatter, Joshua A.
AU - Takahashi, Tsuyoshi
AU - Mittler, Brigitte
AU - Nava, Ruben G.
AU - Puri, Varun
AU - Kreisel, Daniel
AU - Wang, David
N1 - Publisher Copyright:
Copyright © 2020 The Author(s).
PY - 2020
Y1 - 2020
N2 - Background. Primary graft dysfunction (PGD) is the leading cause of early death in lung transplant. Anelloviruses are small circular DNA viruses that have been noted to be present at elevated levels in immunosuppressed patients. They have been associated with both short- and long-term outcomes in lung transplant, and we hypothesized that anellovirus dynamics might be associated with the development of PGD. Methods. We analyzed alphatorquevirus (ie, an anellovirus genus) levels in whole blood samples from 64 adult lung transplant recipients. Results. Patients with a relatively rapid rise in alphatorquevirus levels in the week following transplant were less likely to develop higher-grade PGD over the first 3 days following transplant (P = 0.031). Conclusions. This study is the first to establish an association between the development of PGD and a component of the blood virome. While it is not known whether anelloviruses directly affect outcomes in lung transplant, they may serve as a biomarker of immune status in lung transplant recipients.
AB - Background. Primary graft dysfunction (PGD) is the leading cause of early death in lung transplant. Anelloviruses are small circular DNA viruses that have been noted to be present at elevated levels in immunosuppressed patients. They have been associated with both short- and long-term outcomes in lung transplant, and we hypothesized that anellovirus dynamics might be associated with the development of PGD. Methods. We analyzed alphatorquevirus (ie, an anellovirus genus) levels in whole blood samples from 64 adult lung transplant recipients. Results. Patients with a relatively rapid rise in alphatorquevirus levels in the week following transplant were less likely to develop higher-grade PGD over the first 3 days following transplant (P = 0.031). Conclusions. This study is the first to establish an association between the development of PGD and a component of the blood virome. While it is not known whether anelloviruses directly affect outcomes in lung transplant, they may serve as a biomarker of immune status in lung transplant recipients.
UR - http://www.scopus.com/inward/record.url?scp=85083899049&partnerID=8YFLogxK
U2 - 10.1097/TXD.0000000000000969
DO - 10.1097/TXD.0000000000000969
M3 - Article
C2 - 32095507
AN - SCOPUS:85083899049
JO - Transplantation Direct
JF - Transplantation Direct
SN - 2373-8731
M1 - e521
ER -