TY - JOUR
T1 - Anellovirus Dynamics Are Associated With Primary Graft Dysfunction in Lung Transplantation
AU - Blatter, Joshua A.
AU - Takahashi, Tsuyoshi
AU - Mittler, Brigitte
AU - Nava, Ruben G.
AU - Puri, Varun
AU - Kreisel, Daniel
AU - Wang, David
N1 - Funding Information:
We thank modeling groups for making available their model output through the MJOTF/GASS MJO project. The multimodel output collected by this project and analyzed in this study is available for free download from https://earthsystemcog.org/projects/gassyotc-mip/. We acknowledge the insightful comments from the Editor, C. Zhang, and two anonymous reviewers. The author is indebted to E. Maloney, M. Zhao, D. Waliser, B. Wang, M. Pritchard, and WGNE MJO Task Force members for stimulating discussions during the course of this study. X. Jiang acknowledges support by the National Science Foundation (NSF) Climate and Large-Scale Dynamics Program under award AGS-1228302 and NOAA Climate Program Office MAPP program under awards NA12OAR4310075, NA15OAR4310098, and CVP program under award NA15OAR4310177.
Publisher Copyright:
© 2020 Wolters Kluwer Health. All rights reserved.
PY - 2020/2/13
Y1 - 2020/2/13
N2 - Background. Primary graft dysfunction (PGD) is the leading cause of early death in lung transplant. Anelloviruses are small circular DNA viruses that have been noted to be present at elevated levels in immunosuppressed patients. They have been associated with both short- A nd long-term outcomes in lung transplant, and we hypothesized that anellovirus dynamics might be associated with the development of PGD. Methods. We analyzed alphatorquevirus (ie, an anellovirus genus) levels in whole blood samples from 64 adult lung transplant recipients. Results. Patients with a relatively rapid rise in alphatorquevirus levels in the week following transplant were less likely to develop higher-grade PGD over the first 3 days following transplant (P = 0.031). Conclusions. This study is the first to establish an association between the development of PGD and a component of the blood virome. While it is not known whether anelloviruses directly affect outcomes in lung transplant, they may serve as a biomarker of immune status in lung transplant recipients.
AB - Background. Primary graft dysfunction (PGD) is the leading cause of early death in lung transplant. Anelloviruses are small circular DNA viruses that have been noted to be present at elevated levels in immunosuppressed patients. They have been associated with both short- A nd long-term outcomes in lung transplant, and we hypothesized that anellovirus dynamics might be associated with the development of PGD. Methods. We analyzed alphatorquevirus (ie, an anellovirus genus) levels in whole blood samples from 64 adult lung transplant recipients. Results. Patients with a relatively rapid rise in alphatorquevirus levels in the week following transplant were less likely to develop higher-grade PGD over the first 3 days following transplant (P = 0.031). Conclusions. This study is the first to establish an association between the development of PGD and a component of the blood virome. While it is not known whether anelloviruses directly affect outcomes in lung transplant, they may serve as a biomarker of immune status in lung transplant recipients.
UR - http://www.scopus.com/inward/record.url?scp=85083899049&partnerID=8YFLogxK
U2 - 10.1097/TXD.0000000000000969
DO - 10.1097/TXD.0000000000000969
M3 - Article
C2 - 32095507
AN - SCOPUS:85083899049
SN - 2373-8731
VL - 6
SP - E521
JO - Transplantation Direct
JF - Transplantation Direct
IS - 2
ER -