Anchoring Notch genetics and biochemistry: Structural analysis of the ankyrin domain sheds light on existing data

Olga Y. Lubman; Sergey V. Korolev; Raphael Kopan

doi:10.1016/S1097-2765(04)00120-0

Anchoring Notch genetics and biochemistry: Structural analysis of the ankyrin domain sheds light on existing data

Olga Y. Lubman, Sergey V. Korolev, Raphael Kopan

Division of Immunobiology

Research output: Contribution to journal › Review article › peer-review

89 Scopus citations

Abstract

Notch signaling is important in development and in human disease. Notch receptors regulate transcription through direct interactions with several proteins at the promoter regions of target genes. To understand the mechanism of Notch signaling, numerous deletion and mutagenesis studies have been carried out to identify functional domains in Notch, but domain definition and their role during the assembly of the transcriptionally active complex remains controversial. Recently reported biophysical and structural studies of the Notch ANK domain permit us to reevaluate the existing domain assignments and their predicted functional role, thereby providing further insight into the mechanism of Notch signaling.

Original language	English
Pages (from-to)	619-626
Number of pages	8
Journal	Molecular cell
Volume	13
Issue number	5
DOIs	https://doi.org/10.1016/S1097-2765(04)00120-0
State	Published - Mar 5 2004

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title = "Anchoring Notch genetics and biochemistry: Structural analysis of the ankyrin domain sheds light on existing data",

abstract = "Notch signaling is important in development and in human disease. Notch receptors regulate transcription through direct interactions with several proteins at the promoter regions of target genes. To understand the mechanism of Notch signaling, numerous deletion and mutagenesis studies have been carried out to identify functional domains in Notch, but domain definition and their role during the assembly of the transcriptionally active complex remains controversial. Recently reported biophysical and structural studies of the Notch ANK domain permit us to reevaluate the existing domain assignments and their predicted functional role, thereby providing further insight into the mechanism of Notch signaling.",

author = "Lubman, {Olga Y.} and Korolev, {Sergey V.} and Raphael Kopan",

note = "Funding Information: We are indebted to Dr. Gabriel Waksman for his support and encouragement during the early phases of this work and to Dr. Malu Tansey for critical reading of the manuscript; to both we are grateful for many thoughtful discussions. R.K. is supported by NIH grant GM55479, O.Y.L. by a fellowship from the Keck foundation, S.V.K. by the E.A. Doisy Trust.",

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T2 - Structural analysis of the ankyrin domain sheds light on existing data

AU - Lubman, Olga Y.

AU - Korolev, Sergey V.

AU - Kopan, Raphael

N1 - Funding Information: We are indebted to Dr. Gabriel Waksman for his support and encouragement during the early phases of this work and to Dr. Malu Tansey for critical reading of the manuscript; to both we are grateful for many thoughtful discussions. R.K. is supported by NIH grant GM55479, O.Y.L. by a fellowship from the Keck foundation, S.V.K. by the E.A. Doisy Trust.

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N2 - Notch signaling is important in development and in human disease. Notch receptors regulate transcription through direct interactions with several proteins at the promoter regions of target genes. To understand the mechanism of Notch signaling, numerous deletion and mutagenesis studies have been carried out to identify functional domains in Notch, but domain definition and their role during the assembly of the transcriptionally active complex remains controversial. Recently reported biophysical and structural studies of the Notch ANK domain permit us to reevaluate the existing domain assignments and their predicted functional role, thereby providing further insight into the mechanism of Notch signaling.

AB - Notch signaling is important in development and in human disease. Notch receptors regulate transcription through direct interactions with several proteins at the promoter regions of target genes. To understand the mechanism of Notch signaling, numerous deletion and mutagenesis studies have been carried out to identify functional domains in Notch, but domain definition and their role during the assembly of the transcriptionally active complex remains controversial. Recently reported biophysical and structural studies of the Notch ANK domain permit us to reevaluate the existing domain assignments and their predicted functional role, thereby providing further insight into the mechanism of Notch signaling.

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DO - 10.1016/S1097-2765(04)00120-0

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AN - SCOPUS:1642344776

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Anchoring Notch genetics and biochemistry: Structural analysis of the ankyrin domain sheds light on existing data

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