TY - JOUR
T1 - ANCA-positive vasculitis associated with simvastatin/ezetimibe
T2 - Expanding the spectrum of statin-induced autoimmunity?
AU - Sen, Deepali
AU - Rosenstein, Elliot D.
AU - Kramer, Neil
PY - 2010/8
Y1 - 2010/8
N2 - Although autoimmune syndromes such as systemic lupus erythematosus and dermatomyositis have been previously reported in association with statin use, vasculitis has not been well described. We present a patient with an antineutrophil cytoplasmic antibody-positive, predominantly cutaneous vasculitis, the temporal course of which was associated with simvastatin/ezetimibe use. The patient's serologic findings were consistent with drug-induced disease, with high titer antimyeloperoxidase, in addition to antinuclear and anti-Ro (SSA) antibodies. The patient demonstrated complete resolution of symptoms simply by withdrawing the drug.
AB - Although autoimmune syndromes such as systemic lupus erythematosus and dermatomyositis have been previously reported in association with statin use, vasculitis has not been well described. We present a patient with an antineutrophil cytoplasmic antibody-positive, predominantly cutaneous vasculitis, the temporal course of which was associated with simvastatin/ezetimibe use. The patient's serologic findings were consistent with drug-induced disease, with high titer antimyeloperoxidase, in addition to antinuclear and anti-Ro (SSA) antibodies. The patient demonstrated complete resolution of symptoms simply by withdrawing the drug.
KW - ANCA
KW - Autoimmune diseases
KW - Statins
KW - Vasculitis
UR - http://www.scopus.com/inward/record.url?scp=77955342931&partnerID=8YFLogxK
U2 - 10.1111/j.1756-185X.2010.01481.x
DO - 10.1111/j.1756-185X.2010.01481.x
M3 - Article
C2 - 20704607
AN - SCOPUS:77955342931
VL - 13
SP - e29-e31
JO - International Journal of Rheumatic Diseases
JF - International Journal of Rheumatic Diseases
SN - 1756-1841
IS - 3
ER -