Anatomically constrained reconstruction from noisy data

Justin P. Haldar, Diego Hernando, Sheng Kwei Song, Zhi Pei Liang

Research output: Contribution to journalArticle

73 Scopus citations


Noise is a major concern in many important imaging applications. To improve data signal-to-noise ratio (SNR), experiments often focus on collecting low-frequency k-space data. This article proposes a new scheme to enable extended k-space sampling in these contexts. It is shown that the degradation in SNR associated with extended sampling can be effectively mitigated by using statistical modeling in concert with anatomical prior information. The method represents a significant departure from most existing anatomically constrained imaging methods, which rely on anatomical information to achieve super-resolution. The method has the advantage that less accurate anatomical information is required relative to super-resolution approaches. Theoretical and experimental results are provided to characterize the performance of the proposed scheme.

Original languageEnglish
Pages (from-to)810-818
Number of pages9
JournalMagnetic resonance in medicine
Issue number4
StatePublished - Apr 1 2008


  • Anatomical prior
  • Constrained image reconstruction
  • High resolution

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