Anatomical structures, cell types and biomarkers of the Human Reference Atlas

Katy Börner; Sarah A. Teichmann; Ellen M. Quardokus; James C. Gee; Kristen Browne; David Osumi-Sutherland; Bruce W. Herr; Andreas Bueckle; Hrishikesh Paul; Muzlifah Haniffa; Laura Jardine; Amy Bernard; Song Lin Ding; Jeremy A. Miller; Shin Lin; Marc K. Halushka; Avinash Boppana; Teri A. Longacre; John Hickey; Yiing Lin; M. Todd Valerius; Yongqun He; Gloria Pryhuber; Xin Sun; Marda Jorgensen; Andrea J. Radtke; Clive Wasserfall; Fiona Ginty; Jonhan Ho; Joel Sunshine; Rebecca T. Beuschel; Maigan Brusko; Sujin Lee; Rajeev Malhotra; Sanjay Jain; Griffin Weber

doi:10.1038/s41556-021-00788-6

Anatomical structures, cell types and biomarkers of the Human Reference Atlas

Katy Börner, Sarah A. Teichmann, Ellen M. Quardokus, James C. Gee, Kristen Browne, David Osumi-Sutherland, Bruce W. Herr, Andreas Bueckle, Hrishikesh Paul, Muzlifah Haniffa, Laura Jardine, Amy Bernard, Song Lin Ding, Jeremy A. Miller, Shin Lin, Marc K. Halushka, Avinash Boppana, Teri A. Longacre, John Hickey, Yiing LinM. Todd Valerius, Yongqun He, Gloria Pryhuber, Xin Sun, Marda Jorgensen, Andrea J. Radtke, Clive Wasserfall, Fiona Ginty, Jonhan Ho, Joel Sunshine, Rebecca T. Beuschel, Maigan Brusko, Sujin Lee, Rajeev Malhotra, Sanjay Jain, Griffin Weber

Research output: Contribution to journal › Review article › peer-review

57 Scopus citations

Abstract

The Human Reference Atlas (HRA) aims to map all of the cells of the human body to advance biomedical research and clinical practice. This Perspective presents collaborative work by members of 16 international consortia on two essential and interlinked parts of the HRA: (1) three-dimensional representations of anatomy that are linked to (2) tables that name and interlink major anatomical structures, cell types, plus biomarkers (ASCT+B). We discuss four examples that demonstrate the practical utility of the HRA.

Original language	English
Pages (from-to)	1117-1128
Number of pages	12
Journal	Nature Cell Biology
Volume	23
Issue number	11
DOIs	https://doi.org/10.1038/s41556-021-00788-6
State	Published - Nov 2021

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Börner, K., Teichmann, S. A., Quardokus, E. M., Gee, J. C., Browne, K., Osumi-Sutherland, D., Herr, B. W., Bueckle, A., Paul, H., Haniffa, M., Jardine, L., Bernard, A., Ding, S. L., Miller, J. A., Lin, S., Halushka, M. K., Boppana, A., Longacre, T. A., Hickey, J., ... Weber, G. (2021). Anatomical structures, cell types and biomarkers of the Human Reference Atlas. Nature Cell Biology, 23(11), 1117-1128. https://doi.org/10.1038/s41556-021-00788-6

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title = "Anatomical structures, cell types and biomarkers of the Human Reference Atlas",

abstract = "The Human Reference Atlas (HRA) aims to map all of the cells of the human body to advance biomedical research and clinical practice. This Perspective presents collaborative work by members of 16 international consortia on two essential and interlinked parts of the HRA: (1) three-dimensional representations of anatomy that are linked to (2) tables that name and interlink major anatomical structures, cell types, plus biomarkers (ASCT+B). We discuss four examples that demonstrate the practical utility of the HRA.",

author = "Katy B{\"o}rner and Teichmann, {Sarah A.} and Quardokus, {Ellen M.} and Gee, {James C.} and Kristen Browne and David Osumi-Sutherland and Herr, {Bruce W.} and Andreas Bueckle and Hrishikesh Paul and Muzlifah Haniffa and Laura Jardine and Amy Bernard and Ding, {Song Lin} and Miller, {Jeremy A.} and Shin Lin and Halushka, {Marc K.} and Avinash Boppana and Longacre, {Teri A.} and John Hickey and Yiing Lin and Valerius, {M. Todd} and Yongqun He and Gloria Pryhuber and Xin Sun and Marda Jorgensen and Radtke, {Andrea J.} and Clive Wasserfall and Fiona Ginty and Jonhan Ho and Joel Sunshine and Beuschel, {Rebecca T.} and Maigan Brusko and Sujin Lee and Rajeev Malhotra and Sanjay Jain and Griffin Weber",

note = "Publisher Copyright: {\textcopyright} 2021, Springer Nature Limited.",

year = "2021",

month = nov,

doi = "10.1038/s41556-021-00788-6",

language = "English",

volume = "23",

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journal = "Nature Cell Biology",

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Börner, K, Teichmann, SA, Quardokus, EM, Gee, JC, Browne, K, Osumi-Sutherland, D, Herr, BW, Bueckle, A, Paul, H, Haniffa, M, Jardine, L, Bernard, A, Ding, SL, Miller, JA, Lin, S, Halushka, MK, Boppana, A, Longacre, TA, Hickey, J, Lin, Y, Valerius, MT, He, Y, Pryhuber, G, Sun, X, Jorgensen, M, Radtke, AJ, Wasserfall, C, Ginty, F, Ho, J, Sunshine, J, Beuschel, RT, Brusko, M, Lee, S, Malhotra, R, Jain, S & Weber, G 2021, 'Anatomical structures, cell types and biomarkers of the Human Reference Atlas', Nature Cell Biology, vol. 23, no. 11, pp. 1117-1128. https://doi.org/10.1038/s41556-021-00788-6

TY - JOUR

T1 - Anatomical structures, cell types and biomarkers of the Human Reference Atlas

AU - Börner, Katy

AU - Teichmann, Sarah A.

AU - Quardokus, Ellen M.

AU - Gee, James C.

AU - Browne, Kristen

AU - Osumi-Sutherland, David

AU - Herr, Bruce W.

AU - Bueckle, Andreas

AU - Paul, Hrishikesh

AU - Haniffa, Muzlifah

AU - Jardine, Laura

AU - Bernard, Amy

AU - Ding, Song Lin

AU - Miller, Jeremy A.

AU - Lin, Shin

AU - Halushka, Marc K.

AU - Boppana, Avinash

AU - Longacre, Teri A.

AU - Hickey, John

AU - Lin, Yiing

AU - Valerius, M. Todd

AU - He, Yongqun

AU - Pryhuber, Gloria

AU - Sun, Xin

AU - Jorgensen, Marda

AU - Radtke, Andrea J.

AU - Wasserfall, Clive

AU - Ginty, Fiona

AU - Ho, Jonhan

AU - Sunshine, Joel

AU - Beuschel, Rebecca T.

AU - Brusko, Maigan

AU - Lee, Sujin

AU - Malhotra, Rajeev

AU - Jain, Sanjay

AU - Weber, Griffin

PY - 2021/11

Y1 - 2021/11

N2 - The Human Reference Atlas (HRA) aims to map all of the cells of the human body to advance biomedical research and clinical practice. This Perspective presents collaborative work by members of 16 international consortia on two essential and interlinked parts of the HRA: (1) three-dimensional representations of anatomy that are linked to (2) tables that name and interlink major anatomical structures, cell types, plus biomarkers (ASCT+B). We discuss four examples that demonstrate the practical utility of the HRA.

AB - The Human Reference Atlas (HRA) aims to map all of the cells of the human body to advance biomedical research and clinical practice. This Perspective presents collaborative work by members of 16 international consortia on two essential and interlinked parts of the HRA: (1) three-dimensional representations of anatomy that are linked to (2) tables that name and interlink major anatomical structures, cell types, plus biomarkers (ASCT+B). We discuss four examples that demonstrate the practical utility of the HRA.

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U2 - 10.1038/s41556-021-00788-6

DO - 10.1038/s41556-021-00788-6

M3 - Review article

C2 - 34750582

AN - SCOPUS:85118889272

SN - 1465-7392

VL - 23

SP - 1117

EP - 1128

JO - Nature Cell Biology

JF - Nature Cell Biology

IS - 11

ER -

Anatomical structures, cell types and biomarkers of the Human Reference Atlas

Abstract

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