@article{fe1cbbfa051b41e4b8f1b65d0d2e6792,
title = "Anatomical structures, cell types and biomarkers of the Human Reference Atlas",
abstract = "The Human Reference Atlas (HRA) aims to map all of the cells of the human body to advance biomedical research and clinical practice. This Perspective presents collaborative work by members of 16 international consortia on two essential and interlinked parts of the HRA: (1) three-dimensional representations of anatomy that are linked to (2) tables that name and interlink major anatomical structures, cell types, plus biomarkers (ASCT+B). We discuss four examples that demonstrate the practical utility of the HRA.",
author = "Katy B{\"o}rner and Teichmann, {Sarah A.} and Quardokus, {Ellen M.} and Gee, {James C.} and Kristen Browne and David Osumi-Sutherland and Herr, {Bruce W.} and Andreas Bueckle and Hrishikesh Paul and Muzlifah Haniffa and Laura Jardine and Amy Bernard and Ding, {Song Lin} and Miller, {Jeremy A.} and Shin Lin and Halushka, {Marc K.} and Avinash Boppana and Longacre, {Teri A.} and John Hickey and Yiing Lin and Valerius, {M. Todd} and Yongqun He and Gloria Pryhuber and Xin Sun and Marda Jorgensen and Radtke, {Andrea J.} and Clive Wasserfall and Fiona Ginty and Jonhan Ho and Joel Sunshine and Beuschel, {Rebecca T.} and Maigan Brusko and Sujin Lee and Rajeev Malhotra and Sanjay Jain and Griffin Weber",
note = "Funding Information: Fig. 1 | Components and construction of the HRA. a, Alphabetical listing of 16 HRA construction efforts (left) linked to the 30 human organs that they study (right). The lungs are studied by ten consortia (orange links). This review focuses on ten organs (bold) plus vasculature. BICCN, Brain Research through Advancing Innovative Neurotechnologies Initiative—Cell Census Network Initiative; CZI, Chan Zuckerberg Initiative; H2020, Horizon 2020; GTEx, Genotype-Tissue Expression project; GUDMAP, GenitoUrinary Developmental Molecular Anatomy Project; HTAN, Human Tumor Atlas Network; MRC, Medical Research Council; RBK, (Re)building the Kidney; SPARC, Stimulating Peripheral Activity to Relieve Conditions; TCGA, The Cancer Genome Atlas. b, The 3D reference objects for major anatomical structures were jointly developed for 11 organs. c, An exemplary ASCT+B table showing anatomical structures (AS) and cell types (CT) and some biomarkers (B) for the glomerulus in the kidneys, annotated with the names of the three entity types (anatomical structures, cell types and biomarkers) and four relationship types (part_of, is_a, located_in and characterize). Note that the is_a relationship exists for cell types and biomarkers. Funding Information: Winfree, IUPUI, for discussions regarding the kidney ASCT+B table; and staff at the KPMP, especially the Tissue Interrogation Sites and the Controlled Cell Vocabulary working group, for guidance and development of the initial sets of ASCT+B kidney tables. We acknowledge L. Yao for segmenting and optimizing the mouse popliteal lymph node model from high-resolution microscopy data. The work was funded, in part, by NIH Awards OT2OD026671, U54DK120058, 1UH3CA246594, 1U54AI142766, 1UG3CA256960, 1UG3HL145609, U54HL145608, U54HL145611, UH3DK114933, DK110814, DK107350, U54HG010426, 1R01HL137811, U01DK107350, U24DK110814, U01HL148861, 1U01HL148867, the NIDDK Kidney Precision Medicine Project grant U2CDK114886, the Intramural Research Program of the National Institute of Allergy and Infectious Diseases (NIAID), Department of Health and Human Services under BCBB Support Services Contract HHSN316201300006W/HHSN27200002, Helmsley Charitable Trust 2018PG-T1D071 and 2004-0381, the Allen Institute, Wellcome-Sanger WT206194, and the Chan Zuckerberg Initiative CZF2019-002442. Publisher Copyright: {\textcopyright} 2021, Springer Nature Limited.",
year = "2021",
month = nov,
doi = "10.1038/s41556-021-00788-6",
language = "English",
volume = "23",
pages = "1117--1128",
journal = "Nature Cell Biology",
issn = "1465-7392",
number = "11",
}