Anatomic Pathology of Hepatocellular Carcinoma: Histopathology Using Classic and New Diagnostic Tools

Meredith E. Pittman; Elizabeth M. Brunt

doi:10.1016/j.cld.2015.01.003

Anatomic Pathology of Hepatocellular Carcinoma: Histopathology Using Classic and New Diagnostic Tools

Meredith E. Pittman
, Elizabeth M. Brunt

Division of Anatomic and Molecular Pathology (AMP)

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

Hepatocellular carcinoma can be diagnosed on a needle biopsy of the liver; however, uncertainty may arise because of the inherent complexity of liver histology. This article aims to provide practicing pathologists with tools for the approach to mass-directed liver biopsies clinically concerning for hepatocellular carcinoma. The examination of routine hematoxylin-eosin stains and the use of ancillary histochemical and immunohistochemical stains are discussed. Sections reviewing liver carcinoma with biphenotypic differentiation and the challenge of dysplastic nodules are included.

Original language	English
Pages (from-to)	239-259
Number of pages	21
Journal	Clinics in Liver Disease
Volume	19
Issue number	2
DOIs	https://doi.org/10.1016/j.cld.2015.01.003
State	Published - May 1 2015

Keywords

Arginase-1
Biphenotypic
Dysplastic nodule
Glutamine synthetase
Glypican-3
Hepatocellular carcinoma
Immunohistochemistry
Liver biopsy

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10.1016/j.cld.2015.01.003

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@article{eec0883806e64deb88d05e99d2f8093c,

title = "Anatomic Pathology of Hepatocellular Carcinoma: Histopathology Using Classic and New Diagnostic Tools",

abstract = "Hepatocellular carcinoma can be diagnosed on a needle biopsy of the liver; however, uncertainty may arise because of the inherent complexity of liver histology. This article aims to provide practicing pathologists with tools for the approach to mass-directed liver biopsies clinically concerning for hepatocellular carcinoma. The examination of routine hematoxylin-eosin stains and the use of ancillary histochemical and immunohistochemical stains are discussed. Sections reviewing liver carcinoma with biphenotypic differentiation and the challenge of dysplastic nodules are included.",

keywords = "Arginase-1, Biphenotypic, Dysplastic nodule, Glutamine synthetase, Glypican-3, Hepatocellular carcinoma, Immunohistochemistry, Liver biopsy",

author = "Pittman, \{Meredith E.\} and Brunt, \{Elizabeth M.\}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2015",

month = may,

day = "1",

doi = "10.1016/j.cld.2015.01.003",

language = "English",

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journal = "Clinics in Liver Disease",

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T1 - Anatomic Pathology of Hepatocellular Carcinoma

T2 - Histopathology Using Classic and New Diagnostic Tools

AU - Pittman, Meredith E.

AU - Brunt, Elizabeth M.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Hepatocellular carcinoma can be diagnosed on a needle biopsy of the liver; however, uncertainty may arise because of the inherent complexity of liver histology. This article aims to provide practicing pathologists with tools for the approach to mass-directed liver biopsies clinically concerning for hepatocellular carcinoma. The examination of routine hematoxylin-eosin stains and the use of ancillary histochemical and immunohistochemical stains are discussed. Sections reviewing liver carcinoma with biphenotypic differentiation and the challenge of dysplastic nodules are included.

AB - Hepatocellular carcinoma can be diagnosed on a needle biopsy of the liver; however, uncertainty may arise because of the inherent complexity of liver histology. This article aims to provide practicing pathologists with tools for the approach to mass-directed liver biopsies clinically concerning for hepatocellular carcinoma. The examination of routine hematoxylin-eosin stains and the use of ancillary histochemical and immunohistochemical stains are discussed. Sections reviewing liver carcinoma with biphenotypic differentiation and the challenge of dysplastic nodules are included.

KW - Arginase-1

KW - Biphenotypic

KW - Dysplastic nodule

KW - Glutamine synthetase

KW - Glypican-3

KW - Hepatocellular carcinoma

KW - Immunohistochemistry

KW - Liver biopsy

UR - https://www.scopus.com/pages/publications/84928825616

U2 - 10.1016/j.cld.2015.01.003

DO - 10.1016/j.cld.2015.01.003

M3 - Review article

C2 - 25921661

AN - SCOPUS:84928825616

SN - 1089-3261

VL - 19

SP - 239

EP - 259

JO - Clinics in Liver Disease

JF - Clinics in Liver Disease

IS - 2

ER -

Anatomic Pathology of Hepatocellular Carcinoma: Histopathology Using Classic and New Diagnostic Tools

Abstract

Keywords

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