Anatomic Pathology of Hepatocellular Carcinoma: Histopathology Using Classic and New Diagnostic Tools

Meredith E. Pittman, Elizabeth M. Brunt

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Hepatocellular carcinoma can be diagnosed on a needle biopsy of the liver; however, uncertainty may arise because of the inherent complexity of liver histology. This article aims to provide practicing pathologists with tools for the approach to mass-directed liver biopsies clinically concerning for hepatocellular carcinoma. The examination of routine hematoxylin-eosin stains and the use of ancillary histochemical and immunohistochemical stains are discussed. Sections reviewing liver carcinoma with biphenotypic differentiation and the challenge of dysplastic nodules are included.

Original languageEnglish
Pages (from-to)239-259
Number of pages21
JournalClinics in Liver Disease
Volume19
Issue number2
DOIs
StatePublished - May 1 2015

Keywords

  • Arginase-1
  • Biphenotypic
  • Dysplastic nodule
  • Glutamine synthetase
  • Glypican-3
  • Hepatocellular carcinoma
  • Immunohistochemistry
  • Liver biopsy

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