Analytical tools and current challenges in the modern era of neuroepigenomics

Ian Maze, Li Shen, Bin Zhang, Benjamin A. Garcia, Ningyi Shao, Amanda Mitchell, Hao Sheng Sun, Schahram Akbarian, C. David Allis, Eric J. Nestler

Research output: Contribution to journalReview articlepeer-review

67 Scopus citations

Abstract

Over the past decade, rapid advances in epigenomics research have extensively characterized critical roles for chromatin regulatory events during normal periods of eukaryotic cell development and plasticity, as well as part of aberrant processes implicated in human disease. Application of such approaches to studies of the CNS, however, is more recent. Here we provide a comprehensive overview of available tools for analyzing neuroepigenomics data, as well as a discussion of pending challenges specific to the field of neuroscience. Integration of numerous unbiased genome-wide and proteomic approaches will be necessary to fully understand the neuroepigenome and the extraordinarily complex nature of the human brain. This will be critical to the development of future diagnostic and therapeutic strategies aimed at alleviating the vast array of heterogeneous and genetically distinct disorders of the CNS.

Original languageEnglish
Pages (from-to)1476-1490
Number of pages15
JournalNature neuroscience
Volume17
Issue number11
DOIs
StatePublished - Oct 28 2014

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