## Abstract

Several mathematical expressions (linear, logarithmic, exponential, power law) have been proposed for the diastolic pressure-volume (P-V) relation. The P-V relation is a major component of the atrioventricular pressure gradient that determines transmitral flow. Which P-V relation applies in the in-vivo setting has not been determined by analysis of echocardiographic transmitral flow data. We sought to determine if alternative P-V relations are distinguishable via transmitral echocardiographic Doppler E-wave analysis. One-dimensional force-displacement analogues of the alternative P-V relations were used in a lumped parameter kinematic model for transmitral flow. E-waves of 17 subjects were analyzed using model-based image processing (MBIP). Root-mean-square-error determined fits of model predicted flow velocity to E-wave contours were similar regardless of the force-displacement relation used. We conclude that the simplest (linear) force-displacement relation is suitable for MBIP of transmitral Doppler flow and quantitative diastolic function assessment.

Original language | English |
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Pages (from-to) | 1266-1267 |

Number of pages | 2 |

Journal | Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings |

Volume | 2 |

State | Published - Dec 1 2002 |

Event | Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States Duration: Oct 23 2002 → Oct 26 2002 |

## Keywords

- Diastolic function
- Echocardiography
- Mathematical modeling