Analysis of transmitral flow velocity contours to differentiate between alternative diastolic pressure-volume relations

B. S. Oommen, M. Karamanoglu, S. J. Kovács

Research output: Contribution to journalConference articlepeer-review

Abstract

Several mathematical expressions (linear, logarithmic, exponential, power law) have been proposed for the diastolic pressure-volume (P-V) relation. The P-V relation is a major component of the atrioventricular pressure gradient that determines transmitral flow. Which P-V relation applies in the in-vivo setting has not been determined by analysis of echocardiographic transmitral flow data. We sought to determine if alternative P-V relations are distinguishable via transmitral echocardiographic Doppler E-wave analysis. One-dimensional force-displacement analogues of the alternative P-V relations were used in a lumped parameter kinematic model for transmitral flow. E-waves of 17 subjects were analyzed using model-based image processing (MBIP). Root-mean-square-error determined fits of model predicted flow velocity to E-wave contours were similar regardless of the force-displacement relation used. We conclude that the simplest (linear) force-displacement relation is suitable for MBIP of transmitral Doppler flow and quantitative diastolic function assessment.

Original languageEnglish
Pages (from-to)1266-1267
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume2
StatePublished - Dec 1 2002
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002

Keywords

  • Diastolic function
  • Echocardiography
  • Mathematical modeling

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