Analysis of INSPPIRE-2 Cohort: Risk Factors and Disease Burden in Children with Acute Recurrent or Chronic Pancreatitis

Aliye Uc, Gretchen A. Cress, Fuchenchu Wang, Maisam Abu-El-Haija, Kate M. Ellery, Douglas S. Fishman, Cheryl E. Gariepy, Tanja Gonska, Tom K. Lin, Quin Y. Liu, Megha Mehta, Asim Maqbool, Brian A. McFerron, Veronique D. Morinville, Chee Y. Ooi, Emily R. Perito, Sarah Jane Schwarzenberg, Zachary M. Sellers, Jose Serrano, Uzma ShahDavid M. Troendle, Michael Wilschanski, Yuhua Zheng, Ying Yuan, Mark E. Lowe

Research output: Contribution to journalArticlepeer-review


Objectives: The objective of this study is to investigate risk factors and disease burden in pediatric acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP). Methods: Data were obtained from INternational Study group of Pediatric Pancreatitis: In search for a cuRE-2 (INSPPIRE-2), the largest multi-center prospective cohort study in pediatric patients with ARP or CP. Results: Of 689 children, 365 had ARP (53%), 324 had CP (47%). CP was more commonly associated with female sex, younger age at first acute pancreatitis (AP) attack, Asian race, family history of CP, lower BMI%, genetic and obstructive factors, PRSS1 mutations and pancreas divisum. CFTR mutations, toxic-metabolic factors, medication use, hypertriglyceridemia, Crohn disease were more common in children with ARP. Constant or frequent abdominal pain, emergency room (ER) visits, hospitalizations, medical, endoscopic or surgical therapies were significantly more common in CP, episodic pain in ARP. A total of 33.1% of children with CP had exocrine pancreatic insufficiency (EPI), 8.7% had diabetes mellitus. Compared to boys, girls were more likely to report pain impacting socialization and school, medical therapies, cholecystectomy, but no increased opioid use. There was no difference in race, ethnicity, age at first AP episode, age at CP diagnosis, duration of disease, risk factors, prevalence of EPI or diabetes between boys and girls. Multivariate analysis revealed that family history of CP, constant pain, obstructive risk factors were predictors of CP. Conclusions: Children with family history of CP, constant pain, or obstructive risk factors should raise suspicion for CP.

Original languageEnglish
Pages (from-to)643-649
Number of pages7
JournalJournal of pediatric gastroenterology and nutrition
Issue number5
StatePublished - Nov 1 2022


  • acute recurrent pancreatitis
  • children
  • chronic pancreatitis
  • diabetes
  • exocrine pancreatic insufficiency


Dive into the research topics of 'Analysis of INSPPIRE-2 Cohort: Risk Factors and Disease Burden in Children with Acute Recurrent or Chronic Pancreatitis'. Together they form a unique fingerprint.

Cite this