TY - JOUR
T1 - Analysis of INSPPIRE-2 Cohort
T2 - Risk Factors and Disease Burden in Children with Acute Recurrent or Chronic Pancreatitis
AU - Uc, Aliye
AU - Cress, Gretchen A.
AU - Wang, Fuchenchu
AU - Abu-El-Haija, Maisam
AU - Ellery, Kate M.
AU - Fishman, Douglas S.
AU - Gariepy, Cheryl E.
AU - Gonska, Tanja
AU - Lin, Tom K.
AU - Liu, Quin Y.
AU - Mehta, Megha
AU - Maqbool, Asim
AU - McFerron, Brian A.
AU - Morinville, Veronique D.
AU - Ooi, Chee Y.
AU - Perito, Emily R.
AU - Schwarzenberg, Sarah Jane
AU - Sellers, Zachary M.
AU - Serrano, Jose
AU - Shah, Uzma
AU - Troendle, David M.
AU - Wilschanski, Michael
AU - Zheng, Yuhua
AU - Yuan, Ying
AU - Lowe, Mark E.
N1 - Funding Information:
Sources of Funding: Research reported in this publication was supported by National Institute of Diabetes and Digestive and Kidney Diseases and National Cancer Institute of the National Institutes of Health under award numbers 2U01 DK108334, 2U01 DK108328, R01 DK118752. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Funding Information:
M.E.L. is on the Board of Directors of the National Pancreas Association and receives royalties from Millipore Inc and UpToDate. T.G. received a research grant from Vertex Pharmaceuticals, and she is a consultant for Cystic Fibrosis Foundation (CFF). A.U. is a member of American Board of Pediatrics, Subboard of Pediatric Gastroenterology, Associate Editor of Pancreatology, and consultant for CFF. S.J.S. is a consultant for UpToDate, Nestle, Abbvie, and the Cystic Fibrosis Foundation, and she has a grant from Gilead. V.D.M. is an Associate Editor for JPGN Reports. The remaining authors report no conflicts of interest.
Publisher Copyright:
© 2022 Lippincott Williams and Wilkins. All rights reserved.
PY - 2022/11/1
Y1 - 2022/11/1
N2 - Objectives: The objective of this study is to investigate risk factors and disease burden in pediatric acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP). Methods: Data were obtained from INternational Study group of Pediatric Pancreatitis: In search for a cuRE-2 (INSPPIRE-2), the largest multi-center prospective cohort study in pediatric patients with ARP or CP. Results: Of 689 children, 365 had ARP (53%), 324 had CP (47%). CP was more commonly associated with female sex, younger age at first acute pancreatitis (AP) attack, Asian race, family history of CP, lower BMI%, genetic and obstructive factors, PRSS1 mutations and pancreas divisum. CFTR mutations, toxic-metabolic factors, medication use, hypertriglyceridemia, Crohn disease were more common in children with ARP. Constant or frequent abdominal pain, emergency room (ER) visits, hospitalizations, medical, endoscopic or surgical therapies were significantly more common in CP, episodic pain in ARP. A total of 33.1% of children with CP had exocrine pancreatic insufficiency (EPI), 8.7% had diabetes mellitus. Compared to boys, girls were more likely to report pain impacting socialization and school, medical therapies, cholecystectomy, but no increased opioid use. There was no difference in race, ethnicity, age at first AP episode, age at CP diagnosis, duration of disease, risk factors, prevalence of EPI or diabetes between boys and girls. Multivariate analysis revealed that family history of CP, constant pain, obstructive risk factors were predictors of CP. Conclusions: Children with family history of CP, constant pain, or obstructive risk factors should raise suspicion for CP.
AB - Objectives: The objective of this study is to investigate risk factors and disease burden in pediatric acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP). Methods: Data were obtained from INternational Study group of Pediatric Pancreatitis: In search for a cuRE-2 (INSPPIRE-2), the largest multi-center prospective cohort study in pediatric patients with ARP or CP. Results: Of 689 children, 365 had ARP (53%), 324 had CP (47%). CP was more commonly associated with female sex, younger age at first acute pancreatitis (AP) attack, Asian race, family history of CP, lower BMI%, genetic and obstructive factors, PRSS1 mutations and pancreas divisum. CFTR mutations, toxic-metabolic factors, medication use, hypertriglyceridemia, Crohn disease were more common in children with ARP. Constant or frequent abdominal pain, emergency room (ER) visits, hospitalizations, medical, endoscopic or surgical therapies were significantly more common in CP, episodic pain in ARP. A total of 33.1% of children with CP had exocrine pancreatic insufficiency (EPI), 8.7% had diabetes mellitus. Compared to boys, girls were more likely to report pain impacting socialization and school, medical therapies, cholecystectomy, but no increased opioid use. There was no difference in race, ethnicity, age at first AP episode, age at CP diagnosis, duration of disease, risk factors, prevalence of EPI or diabetes between boys and girls. Multivariate analysis revealed that family history of CP, constant pain, obstructive risk factors were predictors of CP. Conclusions: Children with family history of CP, constant pain, or obstructive risk factors should raise suspicion for CP.
KW - acute recurrent pancreatitis
KW - children
KW - chronic pancreatitis
KW - diabetes
KW - exocrine pancreatic insufficiency
UR - http://www.scopus.com/inward/record.url?scp=85141004629&partnerID=8YFLogxK
U2 - 10.1097/MPG.0000000000003590
DO - 10.1097/MPG.0000000000003590
M3 - Article
C2 - 35976273
AN - SCOPUS:85141004629
SN - 0277-2116
VL - 75
SP - 643
EP - 649
JO - Journal of Pediatric Gastroenterology and Nutrition
JF - Journal of Pediatric Gastroenterology and Nutrition
IS - 5
ER -