Analysis of cardiac diastolic function: Application in coronary artery disease

T. R. Miller, K. J. Goldman, K. S. Sampathkumaran, D. R. Biello, P. A. Ludbrook, B. E. Sobel

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

Separation of systolic and diastolic parameters in gated cardiac blood-pool imaging (RVG) was achieved with the retention of two harmonics in the Fourier-series representation of the time-activity curve. Regional and global analysis of left-ventricular peak filling rate (PFR) and time to peak filling (TPF) was performed in 18 control subjects, 20 patients with coronary artery disease (CAD) but with normal RVG (normal regional wall motion and ejection fraction), and 16 CAD patients with abnormal RVG. In regional analysis of CAD patients, the standard deviation of the TPF histogram identified 13/20 (65%) of normal RVG patients and 12/16 (75%) of abnormal RVG patients as abnormal. In global analysis of CAD patients, PFR values identified 10/20 (50%) of normal RVG patients and 11/16 (69%) of abnormal RVG patients as abnormal. Thus, left-ventricular systolic and diastolic parameters can be separately measured with retention of higher-order harmonics in the Fourier transform, and regional inhomogeneity of diastolic filling can be detected in CAD patients with normal resting ejection fraction and wall motion.

Original languageEnglish
Pages (from-to)2-7
Number of pages6
JournalJournal of Nuclear Medicine
Volume24
Issue number1
StatePublished - Jun 29 1983
Externally publishedYes

Fingerprint Dive into the research topics of 'Analysis of cardiac diastolic function: Application in coronary artery disease'. Together they form a unique fingerprint.

  • Cite this

    Miller, T. R., Goldman, K. J., Sampathkumaran, K. S., Biello, D. R., Ludbrook, P. A., & Sobel, B. E. (1983). Analysis of cardiac diastolic function: Application in coronary artery disease. Journal of Nuclear Medicine, 24(1), 2-7.