@article{6f4169310ab2411281a752f2dee0f0b5,
title = "Analysis of baseline parameters in the HALT polycystic kidney disease trials",
abstract = "HALT PKD consists of two ongoing randomized trials with the largest cohort of systematically studied patients with autosomal dominant polycystic kidney disease to date. Study A will compare combined treatment with an angiotensin-converting inhibitor and receptor blocker to inhibitor alone and standard compared with low blood pressure targets in 558 early-stage disease patients with an eGFR over 60 ml/min per 1.73 m2. Study B will compare inhibitor-blocker treatment to the inhibitor alone in 486 late-stage patients with eGFR 25-60 ml/min per 1.73 m 2. We used correlation and multiple regression cross-sectional analyses to determine associations of baseline parameters with total kidney, liver, or liver cyst volumes measured by MRI in Study A and eGFR in both studies. Lower eGFR and higher natural log-transformed urine albumin excretion were independently associated with a larger natural log-transformed total kidney volume adjusted for height (ln(HtTKV)). Higher body surface area was independently associated with a higher ln(HtTKV) and lower eGFR. Men had larger height-adjusted total kidney volume and smaller liver cyst volumes than women. A weak correlation was found between the ln(HtTKV) and natural log-transformed total liver volume adjusted for height or natural log liver cyst volume in women only. Women had higher urine aldosterone excretion and lower plasma potassium. Thus, our analysis (1) confirms a strong association between renal volume and functional parameters, (2) shows that gender and other factors differentially affect the development of polycystic disease in the kidney and liver, and (3) suggests an association between anthropomorphic measures reflecting prenatal and/or postnatal growth and disease severity.",
keywords = "ADPKD, chronic renal disease, kidney volume, polycystic kidney disease, renal function",
author = "Torres, {Vicente E.} and Chapman, {Arlene B.} and Perrone, {Ronald D.} and Bae, {K. Ty} and Abebe, {Kaleab Z.} and Bost, {James E.} and Miskulin, {Dana C.} and Steinman, {Theodore I.} and Braun, {William E.} and Winklhofer, {Franz T.} and Hogan, {Marie C.} and Oskoui, {Frederic R.} and Cass Kelleher and Amirali Masoumi and James Glockner and Halin, {Neil J.} and Martin, {Diego R.} and Erick Remer and Nayana Patel and Ivan Pedrosa and Wetzel, {Louis H.} and Thompson, {Paul A.} and Miller, {J. Philip} and Meyers, {Catherine M.} and Schrier, {Robert W.}",
note = "Funding Information: This study is supported by cooperative agreements (DK62408, DK62401, DK62410, DK62402, and DK62411) with the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, the NCRR GCRCs (RR000039 Emory University, RR00585 Mayo Clinic, RR000054 Tufts University, RR000051 University of Colorado, RR23940 Kansas University, and RR024296, Beth Israel Deaconess Medical Center), and the Centers for Translational Science Activities at the participating institutions (RR025008 Emory University, RR024150 Mayo Clinic, RR025752 Tufts University, RR025780 University of Colorado, and RR024989 Cleveland Clinic). Support for the study enrollment phase was also provided by grants to the participating clinical centers from the PKD Research Foundation. Study drugs were donated by Boehringer Ingelheim Pharmaceuticals (telmisartan and placebo) and Merck (lisinopril). The HALT Study Group is indebted to the study subjects for taking part in the study, the Research Program Coordinators and Program Managers at the Washington University (Gigi Flynn and Robin Woltman) and University of Pittsburgh (Andrea Erfort and Patty Smith), and the study coordinators at the clinical centers (Darlene Baker, Julie Driggs, Maria Fishman, Stacie Hitchcock, Andee Jolley, Pamela Lanza, Bonnie Maxwell, Pamela Morgan, Kristine Otto, Heather Ondler, Linda Perkins, Gertrude Simon, Rita Spirko, Diane Watkins) who made this research possible.",
year = "2012",
month = mar,
day = "2",
doi = "10.1038/ki.2011.411",
language = "English",
volume = "81",
pages = "577--585",
journal = "Kidney International",
issn = "0085-2538",
number = "6",
}