Analysis of a 1-Mb BAC contig overlapping the mouse Nkrp1 cluster of genes: Cloning of three new Nkrp1 members, Nkrp1d, Nkrp1e, and Nkrp1f

B. Plougastel, K. Matsumoto, C. Dubbelde, W. M. Yokoyama

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

The murine Nkrp1 gene family encodes three previously identified activation and inhibitory receptors expressed on natural killer (NK) cells, This family includes the gene for NKR-P1C (NK1.1), the most specific serologic marker on C57BL/6-derived NK cells and is localized in a gene cluster in the NK gene complex (NKC). To further analyze the Nkrp1 family, we constructed and analyzed a bacterial artificial chromosome contig. A genomic organization of the Nkrp1 family was obtained and three new Nkrp1 genes were isolated from interleukin-2-activated NK cells. Thus, the Nkrp1 family adds to the repertoire of receptors expressed by NK cells.

Original languageEnglish
Pages (from-to)592-598
Number of pages7
JournalImmunogenetics
Volume53
Issue number7
DOIs
StatePublished - Jan 1 2001

Keywords

  • Cd69
  • Cluster
  • NKC
  • NKR-P1

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