Analysis of a 1-Mb BAC contig overlapping the mouse Nkrp1 cluster of genes: Cloning of three new Nkrp1 members, Nkrp1d, Nkrp1e, and Nkrp1f

B. Plougastel; K. Matsumoto; C. Dubbelde; W. M. Yokoyama

doi:10.1007/s002510100367

Analysis of a 1-Mb BAC contig overlapping the mouse Nkrp1 cluster of genes: Cloning of three new Nkrp1 members, Nkrp1d, Nkrp1e, and Nkrp1f

B. Plougastel, K. Matsumoto, C. Dubbelde, W. M. Yokoyama

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45 Scopus citations

Abstract

The murine Nkrp1 gene family encodes three previously identified activation and inhibitory receptors expressed on natural killer (NK) cells, This family includes the gene for NKR-P1C (NK1.1), the most specific serologic marker on C57BL/6-derived NK cells and is localized in a gene cluster in the NK gene complex (NKC). To further analyze the Nkrp1 family, we constructed and analyzed a bacterial artificial chromosome contig. A genomic organization of the Nkrp1 family was obtained and three new Nkrp1 genes were isolated from interleukin-2-activated NK cells. Thus, the Nkrp1 family adds to the repertoire of receptors expressed by NK cells.

Original language	English
Pages (from-to)	592-598
Number of pages	7
Journal	Immunogenetics
Volume	53
Issue number	7
DOIs	https://doi.org/10.1007/s002510100367
State	Published - 2001

Keywords

Cd69
Cluster
NKC
NKR-P1

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10.1007/s002510100367

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title = "Analysis of a 1-Mb BAC contig overlapping the mouse Nkrp1 cluster of genes: Cloning of three new Nkrp1 members, Nkrp1d, Nkrp1e, and Nkrp1f",

abstract = "The murine Nkrp1 gene family encodes three previously identified activation and inhibitory receptors expressed on natural killer (NK) cells, This family includes the gene for NKR-P1C (NK1.1), the most specific serologic marker on C57BL/6-derived NK cells and is localized in a gene cluster in the NK gene complex (NKC). To further analyze the Nkrp1 family, we constructed and analyzed a bacterial artificial chromosome contig. A genomic organization of the Nkrp1 family was obtained and three new Nkrp1 genes were isolated from interleukin-2-activated NK cells. Thus, the Nkrp1 family adds to the repertoire of receptors expressed by NK cells.",

keywords = "Cd69, Cluster, NKC, NKR-P1",

author = "B. Plougastel and K. Matsumoto and C. Dubbelde and Yokoyama, {W. M.}",

note = "Funding Information: Acknowledgements This work was supported by NIH grants to W.M.Y. who is an investigator at the Howard Hughes Medical Institute.",

year = "2001",

doi = "10.1007/s002510100367",

language = "English",

volume = "53",

pages = "592--598",

journal = "Immunogenetics",

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T1 - Analysis of a 1-Mb BAC contig overlapping the mouse Nkrp1 cluster of genes

T2 - Cloning of three new Nkrp1 members, Nkrp1d, Nkrp1e, and Nkrp1f

AU - Plougastel, B.

AU - Matsumoto, K.

AU - Dubbelde, C.

AU - Yokoyama, W. M.

N1 - Funding Information: Acknowledgements This work was supported by NIH grants to W.M.Y. who is an investigator at the Howard Hughes Medical Institute.

PY - 2001

Y1 - 2001

N2 - The murine Nkrp1 gene family encodes three previously identified activation and inhibitory receptors expressed on natural killer (NK) cells, This family includes the gene for NKR-P1C (NK1.1), the most specific serologic marker on C57BL/6-derived NK cells and is localized in a gene cluster in the NK gene complex (NKC). To further analyze the Nkrp1 family, we constructed and analyzed a bacterial artificial chromosome contig. A genomic organization of the Nkrp1 family was obtained and three new Nkrp1 genes were isolated from interleukin-2-activated NK cells. Thus, the Nkrp1 family adds to the repertoire of receptors expressed by NK cells.

AB - The murine Nkrp1 gene family encodes three previously identified activation and inhibitory receptors expressed on natural killer (NK) cells, This family includes the gene for NKR-P1C (NK1.1), the most specific serologic marker on C57BL/6-derived NK cells and is localized in a gene cluster in the NK gene complex (NKC). To further analyze the Nkrp1 family, we constructed and analyzed a bacterial artificial chromosome contig. A genomic organization of the Nkrp1 family was obtained and three new Nkrp1 genes were isolated from interleukin-2-activated NK cells. Thus, the Nkrp1 family adds to the repertoire of receptors expressed by NK cells.

KW - Cd69

KW - Cluster

KW - NKC

KW - NKR-P1

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U2 - 10.1007/s002510100367

DO - 10.1007/s002510100367

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AN - SCOPUS:0034767431

SN - 0093-7711

VL - 53

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EP - 598

JO - Immunogenetics

JF - Immunogenetics

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ER -

Analysis of a 1-Mb BAC contig overlapping the mouse Nkrp1 cluster of genes: Cloning of three new Nkrp1 members, Nkrp1d, Nkrp1e, and Nkrp1f

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Keywords

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