Analogues of oxy-heme Aβ: Reactive intermediates relevant to Alzheimer’s disease

Manas Seal; Soumya Mukherjee; Debajyoti Pramanik; Kaustuv Mittra; Abhishek Dey; Somdatta Ghosh Dey

doi:10.1039/c2cc37626a

Analogues of oxy-heme Aβ: Reactive intermediates relevant to Alzheimer’s disease

Manas Seal, Soumya Mukherjee, Debajyoti Pramanik, Kaustuv Mittra, Abhishek Dey, Somdatta Ghosh Dey

Hope Center for Neurological Disorders

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Redox active metals (Fe and Cu) and cofactors (heme) bind to Aβ peptides and react with O₂ in their reduced state leading to oxidative stress in the brain. In this study we cryogenically trap and characterize a Fe-O₂ intermediate, using resonance Raman spectroscopy, involved in reactive oxygen species formation by Aβ peptides. This is the first reaction intermediate relevant to Alzheimer's disease to be reported.

Original language	English
Pages (from-to)	1091-1093
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	11
DOIs	https://doi.org/10.1039/c2cc37626a
State	Published - Jan 10 2013

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AU - Mittra, Kaustuv

AU - Dey, Abhishek

AU - Dey, Somdatta Ghosh

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AB - Redox active metals (Fe and Cu) and cofactors (heme) bind to Aβ peptides and react with O2 in their reduced state leading to oxidative stress in the brain. In this study we cryogenically trap and characterize a Fe-O2 intermediate, using resonance Raman spectroscopy, involved in reactive oxygen species formation by Aβ peptides. This is the first reaction intermediate relevant to Alzheimer's disease to be reported.

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Analogues of oxy-heme Aβ: Reactive intermediates relevant to Alzheimer’s disease

Abstract

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