Abstract

Three analogs of bradykinin have been synthesized which bear an α-methyl group in the place of an α proton at position 4, 5, or 8. Such analogs possess restricted conformational freedom and are of interest for three reasons. (1) They may provide information about the receptor-bound conformation of the peptide. (2) They may provide a route to antagonists of the native peptide. (3) They may be degraded slowly by proteolytic enzymes. None of the analogs described here antagonized the action of bradykinin, but one exhibited tissue specificity and decreased pulmonary inactivation in the rat.

Original languageEnglish
Pages (from-to)1139-1142
Number of pages4
JournalJournal of Medicinal Chemistry
Volume18
Issue number11
DOIs
StatePublished - Nov 1 1975

Fingerprint Dive into the research topics of 'Analogs of Bradykinin with Restricted Conformational Freedom'. Together they form a unique fingerprint.

  • Cite this