Analogs of 3′-Amino-3′-Deoxyadenosine Inhibit HIV-1 Replication

Nancy Vander Heyden, Charles Rodi, Lee Ratner

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Several different nucleoside analogs have been demonstrated to inhibit retroviral RNA-dependent DNA polymerase activity in preference to cellular DNA-dependent DNA polymerases. 3′-Amino derivatives of 3-deoxyadenosine was analyzed for their antiviral activity toward HIV-1 and for their host cell toxicity. Puromycin aminonucleoside (PANS), PANS 5′-monophosphate, and 3′-amino-3′-deoxyadenosine triphosphate all inhibited HIV-1 replication in acutely infected cells. No significant antiviral effects of PANS were demonstrated in chronically infected cells. The effect of PANS was demonstrated at an early step in HIV-1 replication, most likely reverse transcription. 3′-Aminonucleoside analogs are a novel class of inhibitors of HIV-1 replication that require further analysis in cell culture and animal studies.

Original languageEnglish
Pages (from-to)647-653
Number of pages7
JournalAIDS research and human retroviruses
Volume5
Issue number6
DOIs
StatePublished - Dec 1989

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