An update on the current genomic landscape of breast implant-associated anaplastic large cell lymphoma

Sean Harrop, Neha Mehta-Shah, Criselle Dsouza, Ella Thompson, Anand Deva, Henry Miles Prince

Research output: Contribution to journalArticlepeer-review

Abstract

Breast implant-associated lymphoma (BIA-ALCL) is a rare subtype of anaplastic large-cell lymphoma associated with breast prostheses. Most patients present with a localised periprosthetic effusion and are managed with removal of the implant and surrounding capsule. Less commonly, the lymphoma can form a mass associated with the capsule and rarely can present with disseminated disease. Recent series characterising the genomic landscape of BIA-ALCL have led to insights into the mechanisms of lymphomagenesis. Constitutive JAK/STAT pathway activation has emerged as a likely key component while, more recently, aberrancies in epigenetic regulators have been reported. This review describes the genomic characterisation reported to date and the insight these findings have provided into this rare entity.

Original languageEnglish
Article number4921
JournalCancers
Volume13
Issue number19
DOIs
StatePublished - Oct 1 2021

Keywords

  • Breast implants
  • Epigenetic
  • JAK/STAT

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