An overview of two-component signal transduction systems implicated in extra-intestinal pathogenic E. coli infections

Erin J. Breland, Allison R. Eberly, Maria Hadjifrangiskou

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

Extra-intestinal pathogenic E. coli (ExPEC) infections are common in mammals and birds. The predominant ExPEC types are avian pathogenic E. coli (APEC), neonatal meningitis causing E. coli/meningitis associated E. coli (NMEC/MAEC), and uropathogenic E. coli (UPEC). Many reviews have described current knowledge on ExPEC infection strategies and virulence factors, especially for UPEC. However, surprisingly little has been reported on the regulatory modules that have been identified as critical in ExPEC pathogenesis. Two-component systems (TCSs) comprise the predominant method by which bacteria respond to changing environments and play significant roles in modulating bacterial fitness in diverse niches. Recent studies have highlighted the potential of manipulating signal transduction systems as a means to chemically re-wire bacterial pathogens, thereby reducing selective pressure and avoiding the emergence of antibiotic resistance. This review begins by providing a brief introduction to characterized infection strategies and common virulence factors among APEC, NMEC, and UPEC and continues with a comprehensive overview of two-component signal transduction networks that have been shown to influence ExPEC pathogenesis.

Original languageEnglish
Article number162
JournalFrontiers in cellular and infection microbiology
Volume7
Issue numberMAY
DOIs
StatePublished - May 9 2017

Keywords

  • APEC
  • ExPEC
  • MAEC/NMEC
  • Signal transduction
  • Two-component systems
  • UPEC
  • Virulence factors

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