TY - JOUR
T1 - An overview of treatment options for patients with relapsed/refractory multiple myeloma and renal impairment
AU - Dimopoulos, Meletios A.
AU - Mikhael, Joseph
AU - Terpos, Evangelos
AU - Leleu, Xavier
AU - Moreau, Philippe
AU - Bladé, Joan
AU - Kim, Jin Seok
AU - Stockerl-Goldstein, Keith
AU - Richardson, Paul G.
N1 - Publisher Copyright:
© The Author(s), 2022.
PY - 2022/4
Y1 - 2022/4
N2 - Renal impairment (RI) is a relatively common complication of multiple myeloma, which increases in frequency as disease becomes more advanced and recovery of renal function becomes less likely as patients progress through lines of therapy. Clinical trials in the relapsed/refractory multiple myeloma (RRMM) setting have not uniformly included patients with RI or robustly reported their outcomes. Here, we review existing data among patients with RI and RRMM across drug classes (including immunomodulatory agents, proteasome inhibitors, monoclonal antibodies, antibody-drug conjugates, chimeric antigen receptor T-cell therapies, and exportin-1 inhibitor) to provide an improved understanding of available treatment options for this important population. We highlight data from pivotal clinical trials, including data relating to renal response (as defined by the International Myeloma Working Group) and discuss real-world experiences in patients with RI, where applicable. Despite substantial advances in RRMM treatment, the presence of RI remains associated with reduced overall survival. Consistent inclusion of patients with RI, and uniform reporting of their outcomes, should be encouraged in future prospective trials of treatments for RRMM.
AB - Renal impairment (RI) is a relatively common complication of multiple myeloma, which increases in frequency as disease becomes more advanced and recovery of renal function becomes less likely as patients progress through lines of therapy. Clinical trials in the relapsed/refractory multiple myeloma (RRMM) setting have not uniformly included patients with RI or robustly reported their outcomes. Here, we review existing data among patients with RI and RRMM across drug classes (including immunomodulatory agents, proteasome inhibitors, monoclonal antibodies, antibody-drug conjugates, chimeric antigen receptor T-cell therapies, and exportin-1 inhibitor) to provide an improved understanding of available treatment options for this important population. We highlight data from pivotal clinical trials, including data relating to renal response (as defined by the International Myeloma Working Group) and discuss real-world experiences in patients with RI, where applicable. Despite substantial advances in RRMM treatment, the presence of RI remains associated with reduced overall survival. Consistent inclusion of patients with RI, and uniform reporting of their outcomes, should be encouraged in future prospective trials of treatments for RRMM.
KW - multiple myeloma
KW - refractory
KW - relapsed
KW - renal impairment
KW - renal response
UR - http://www.scopus.com/inward/record.url?scp=85128231632&partnerID=8YFLogxK
U2 - 10.1177/20406207221088458
DO - 10.1177/20406207221088458
M3 - Review article
C2 - 35392438
AN - SCOPUS:85128231632
SN - 2040-6207
VL - 13
JO - Therapeutic Advances in Hematology
JF - Therapeutic Advances in Hematology
ER -