An overview of the use of antidepressants in children and adolescents.

OBJECTIVE: To provide a relevant, evidence-based review of antidepressant use in children for primary care providers. METHOD: Selected published studies, reviews, and guidelines are synthesized. RESULTS: Best evidence supports combination treatment (Selective Serotonin Reuptake Inhibitor plus Cognitive Behavioral Therapy) for Major Depressive Disorder (MDD) and Anxiety disorders. Data for efficacious uses of antidepressants in Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism are scant but emerging. CONCLUSIONS: Despite recent FDA warnings, antidepressants are beneficial for a variety of childhood disorders (including MDD, Anxiety Disorders, ADHD, and Autism).