An overview of the toxicities of checkpoint inhibitors in older patients with cancer

Omar Alkharabsheh, Paul Kannarkatt, Joseph Kannarkatt, Lilit Karapetyan, Heather S. Laird-Fick, Anas Al-Janadi

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Checkpoint inhibitors offer an exciting new option for treatment of a wide variety of cancers. By binding to surface receptors or their associated ligands on T cells, this class of drugs enhances immune activation and response to cancer cells. In available studies, the drugs are well tolerated, although toxicity involving skin, gastrointestinal tract, liver, lungs, and endocrine organs has been observed. Unfortunately, few studies to date have included patients older than 70 years of age. Since aging has been linked to changes in immune function, there are theoretical concerns that this patient population might experience a different profile of adverse events. This article reviews the tolerability of checkpoint inhibitors in older patients with cancer in clinical practice.

Original languageEnglish
Pages (from-to)451-458
Number of pages8
JournalJournal of Geriatric Oncology
Volume9
Issue number5
DOIs
StatePublished - Sep 2018

Keywords

  • Elderly cancer patients
  • Immune checkpoint inhibitors
  • Immune-related adverse events

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