An overview of the serpin superfamily

Ruby H.P. Law, Qingwei Zhang, Sheena McGowan, Ashley M. Buckle, Gary A. Silverman, Wilson Wong, Carlos J. Rosado, Chris G. Langendorf, Rob N. Pike, Philip I. Bird, James C. Whisstock

Research output: Contribution to journalReview articlepeer-review

451 Scopus citations


Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades, including the mammalian coagulation pathways. Serpins are conformationally labile and many of the disease-linked mutations of serpins result in misfolding or in pathogenic, inactive polymers.

Original languageEnglish
Article number216
JournalGenome biology
Issue number5
StatePublished - May 30 2006


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