An overview of polymyositis and dermatomyositis

Andrew R. Findlay, Namita A. Goyal, Tahseen Mozaffar

Research output: Contribution to journalReview article

63 Scopus citations

Abstract

Polymyositis and dermatomyositis are inflammatory myopathies that differ in their clinical features, histopathology, response to treatment, and prognosis. Although their clinical pictures differ, they both present with symmetrical, proximal muscle weakness. Treatment relies mainly upon empirical use of corticosteroids and immunosuppressive agents. A deeper understanding of the molecular pathways that drive pathogenesis, careful phenotyping, and accurate disease classification will aid clinical research and development of more efficacious treatments. In this review we address the current knowledge of the epidemiology, clinical characteristics, diagnostic evaluation, classification, pathogenesis, treatment, and prognosis of polymyositis and dermatomyositis.

Original languageEnglish
Pages (from-to)638-656
Number of pages19
JournalMuscle and Nerve
Volume51
Issue number5
DOIs
StatePublished - May 1 2015

Keywords

  • Dermatomyositis
  • Inclusion-body myositis
  • Inflammatory myopathy
  • Myositis-specific autoantibodies
  • Polymyositis

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