An open-label study of nefazodone in the treatment of depression with and without comorbid obsessive compulsive disorder

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Abstract

An 8-week open-label study of nefazodone treatment of DSM-III-R major depressive episode (MDE) (n = 18) is reported. Nine of 15 individuals completing treatment also met DSM-III-R criteria for obsessive compulsive disorder (OCD). A significant reduction in depressive and anxiety symptoms was observed in treatment completers; no differences were found between those patients with and those without comorbid OCD. A trend toward an antiobsessional response was seen among those with OCD. The degree of anxiolytic response was found to be significantly correlated with the degree of antidepressant response. Nefazodone was well tolerated in most patients, with dizziness, joint pain, dry mouth, and sedation as the most commonly reported adverse events.

Original languageEnglish
Pages (from-to)249-253
Number of pages5
JournalAnnals of Clinical Psychiatry
Volume6
Issue number4
DOIs
StatePublished - Jan 1 1994

Keywords

  • Major depressive disorder
  • Nefazodone
  • Obsessive compulsive disorder

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