@article{a74b5d233b7e41a5bfa8690062a44e54,
title = "An open and closed case for all polymerases",
abstract = "The recently determined structures of HIV-1 reverse transcriptase and Taq DNA polymerase in complex with DNA primer-template and an incoming nucleotide have shown that a large conformational change configures the polymerase active site for nucleotidyl transfer. The structure of reverse transcriptase in the catalytic complex will open the path to the rational design of novel nucleoside analog inhibitors of viral replication.",
author = "Sylvie Doubli{\'e} and Sawaya, {Michael R.} and Tom Ellenberger",
note = "Funding Information: We thank Stephen Harrison, Gregor Verdine, and Gabriel Waksman for providing information and structural coordinates prior to publication. Our work on DNA replication proteins is supported by the National Institutes of Health, the Armenise-Harvard Center for Advanced Scientific Research, and the Harvard Center for Structural Biology. ",
year = "1999",
month = feb,
doi = "10.1016/S0969-2126(99)80017-3",
language = "English",
volume = "7",
pages = "R31--R35",
journal = "Structure",
issn = "0969-2126",
number = "2",
}