An open and closed case for all polymerases

Sylvie Doublié, Michael R. Sawaya, Tom Ellenberger

Research output: Contribution to journalReview articlepeer-review

284 Scopus citations


The recently determined structures of HIV-1 reverse transcriptase and Taq DNA polymerase in complex with DNA primer-template and an incoming nucleotide have shown that a large conformational change configures the polymerase active site for nucleotidyl transfer. The structure of reverse transcriptase in the catalytic complex will open the path to the rational design of novel nucleoside analog inhibitors of viral replication.

Original languageEnglish
Pages (from-to)R31-R35
Issue number2
StatePublished - Feb 1999


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