An iron-carboxylate bond links the heme units of malaria pigment

Andrew F.G. Slater; William J. Swiggard; Brian R. Orton; William D. Flitter; Daniel E. Goldberg; Anthony Cerami; Graeme B. Henderson

doi:10.1073/pnas.88.2.325

An iron-carboxylate bond links the heme units of malaria pigment

Andrew F.G. Slater, William J. Swiggard, Brian R. Orton, William D. Flitter, Daniel E. Goldberg, Anthony Cerami, Graeme B. Henderson

Research output: Contribution to journal › Article › peer-review

477 Scopus citations

Abstract

The intraerythrocytic malaria parasite uses homoglobin as a major nutrient source. Digestion of hemoglobin releases heme, which the parasite converts into an insoluble ocrystalline material called hemozoin or malaria pigment. We have purified hemozoin from the human malaria organism falciparum and have used infrared spectroscopy, absorption spectroscopy, and chemical synthesis to determine its structure. The molecule consists of an unusual of hemes linked between the central ferric ion of one and a carboxylate side-group oxygen of another. The are sequestered via this linkage into an insoluble product, providing a unique way for the malaria parasite to avoid the toxicity associated with soluble heme.

Original language	English
Pages (from-to)	325-329
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	88
Issue number	2
DOIs	https://doi.org/10.1073/pnas.88.2.325
State	Published - 1991

Keywords

Extended x-ray absorption fine structure
Hemoglobin
Hemozoin
Plasmodium

Access to Document

10.1073/pnas.88.2.325

Cite this

@article{72af37982dd44c15a9cba81e01789d17,

title = "An iron-carboxylate bond links the heme units of malaria pigment",

abstract = "The intraerythrocytic malaria parasite uses homoglobin as a major nutrient source. Digestion of hemoglobin releases heme, which the parasite converts into an insoluble ocrystalline material called hemozoin or malaria pigment. We have purified hemozoin from the human malaria organism falciparum and have used infrared spectroscopy, absorption spectroscopy, and chemical synthesis to determine its structure. The molecule consists of an unusual of hemes linked between the central ferric ion of one and a carboxylate side-group oxygen of another. The are sequestered via this linkage into an insoluble product, providing a unique way for the malaria parasite to avoid the toxicity associated with soluble heme.",

keywords = "Extended x-ray absorption fine structure, Hemoglobin, Hemozoin, Plasmodium",

author = "Slater, {Andrew F.G.} and Swiggard, {William J.} and Orton, {Brian R.} and Flitter, {William D.} and Goldberg, {Daniel E.} and Anthony Cerami and Henderson, {Graeme B.}",

year = "1991",

doi = "10.1073/pnas.88.2.325",

language = "English",

volume = "88",

pages = "325--329",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

number = "2",

}

An iron-carboxylate bond links the heme units of malaria pigment. / Slater, Andrew F.G.; Swiggard, William J.; Orton, Brian R.; Flitter, William D.; Goldberg, Daniel E.; Cerami, Anthony; Henderson, Graeme B.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, No. 2, 1991, p. 325-329.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - An iron-carboxylate bond links the heme units of malaria pigment

AU - Slater, Andrew F.G.

AU - Swiggard, William J.

AU - Orton, Brian R.

AU - Flitter, William D.

AU - Goldberg, Daniel E.

AU - Cerami, Anthony

AU - Henderson, Graeme B.

PY - 1991

Y1 - 1991

N2 - The intraerythrocytic malaria parasite uses homoglobin as a major nutrient source. Digestion of hemoglobin releases heme, which the parasite converts into an insoluble ocrystalline material called hemozoin or malaria pigment. We have purified hemozoin from the human malaria organism falciparum and have used infrared spectroscopy, absorption spectroscopy, and chemical synthesis to determine its structure. The molecule consists of an unusual of hemes linked between the central ferric ion of one and a carboxylate side-group oxygen of another. The are sequestered via this linkage into an insoluble product, providing a unique way for the malaria parasite to avoid the toxicity associated with soluble heme.

AB - The intraerythrocytic malaria parasite uses homoglobin as a major nutrient source. Digestion of hemoglobin releases heme, which the parasite converts into an insoluble ocrystalline material called hemozoin or malaria pigment. We have purified hemozoin from the human malaria organism falciparum and have used infrared spectroscopy, absorption spectroscopy, and chemical synthesis to determine its structure. The molecule consists of an unusual of hemes linked between the central ferric ion of one and a carboxylate side-group oxygen of another. The are sequestered via this linkage into an insoluble product, providing a unique way for the malaria parasite to avoid the toxicity associated with soluble heme.

KW - Extended x-ray absorption fine structure

KW - Hemoglobin

KW - Hemozoin

KW - Plasmodium

UR - http://www.scopus.com/inward/record.url?scp=0025959212&partnerID=8YFLogxK

U2 - 10.1073/pnas.88.2.325

DO - 10.1073/pnas.88.2.325

M3 - Article

C2 - 1988933

AN - SCOPUS:0025959212

VL - 88

SP - 325

EP - 329

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 2

ER -

An iron-carboxylate bond links the heme units of malaria pigment

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this