@article{d61d4aa4bddc47ccbe8f4a2af22f0795,
title = "An investigation of candidate regions for association with bipolar disorder",
abstract = "We performed a case-control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8Mb region on chromosome 6 (105-113 Mb). This region has shown evidence of involvement in bipolar disorder (BP) in a number of other studies. We find association between BP and two SNPs in the gene LACE1. SNP rs9486880 and rs11153113 (both have P-values of 2×10-5). Both P-values are in the top 5% of the distribution derived from null simulations (P=0.02 and 0.01, respectively). LACE is a good candidate for BP; it is an ATPase. We genotyped 173 other markers in 17 other positional and/or functional loci but found no further evidence of association with BP.",
keywords = "Association, Bipolar disorder, Genetics",
author = "{NIMH Genetics Initiative Bipolar Disorder Consortium} and Jo Knight and Rochberg, {Nanette S.} and Saccone, {Scott F.} and Nurnberger, {John I.} and Rice, {John P.} and John Nurnberger and Miller, {Marvin J.} and Bowman, {Elizabeth S.} and Rau, {N. Leela} and Moe, {P. Ryan} and Nalini Samavedy and Rif El-Mallakh and Husseini Manji and Glitz, {Debra A.} and Meyer, {Eric T.} and Carrie Smiley and Tatiana Foroud and Leah Flury and Dick, {Danielle M.} and Howard Edenberg and John Rice and Theodore Reich and Allison Goate and Laura Bierut and Melvin McInnis and DePaulo, {J. Raymond} and MacKinnon, {Dean F.} and Mondimore, {Francis M.} and Potash, {James B.} and Zandi, {Peter P.} and Dimitrios Avramopoulos and Jennifer Payne and Wade Berrettini and William Byerley and Sophia Vinogradov and William Coryell and Raymond Crowe and Elliot Gershon and Judith Badner and Francis McMahon and Chunyu Liu and Alan Sanders and Maria Caserta and Steven Dinwiddie and Tu Nguyen and Donna Harakal and John Kelsoe and Rebecca McKinney and William Scheftner and Kravitz, {Howard M.}",
note = "Publisher Copyright: {\textcopyright} 2010 Wiley-Liss, Inc.",
year = "2010",
month = oct,
day = "1",
doi = "10.1002/ajmg.b.31100",
language = "English",
volume = "153",
pages = "1292--1297",
journal = "American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics",
issn = "1552-4841",
number = "7",
}