An introduction to the measurement of the cerebral oxygen uptake rate by inhalation ofl5o2: Analysis of the contribution ofl5o2 and h215o in brain radioactivity

J. C. Depresseux; M. E. Raichle; K. B. Larson; J. Markham; M. M. Ter-Pogossian

doi:10.1159/000115235

An introduction to the measurement of the cerebral oxygen uptake rate by inhalation of^l5o₂: Analysis of the contribution of^l5o₂ and h₂¹⁵o in brain radioactivity

J. C. Depresseux, M. E. Raichle, K. B. Larson, J. Markham, M. M. Ter-Pogossian

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Abstract

This paper introduces a model for the computation of the regional cerebral metabolic rate of oxygen from the data of cerebral regional radioactivity collected after inhalation 0f¹⁵O₂. A method was devised for the differential determination of the respective contribution of radiooxygen and of radiowater in the inflow and the outflow of radioactivity in the brain after or during such on inhalation. The results demonstrate the feasability of such a model and outline some of the methodological prerequisites to be taken into account in the numerical analysis of the data.

Original language	English
Pages (from-to)	207-214
Number of pages	8
Journal	European neurology
Volume	20
Issue number	3
DOIs	https://doi.org/10.1159/000115235
State	Published - Jan 1 1981

Keywords

BrainO
Model
Water metabolism

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abstract = "This paper introduces a model for the computation of the regional cerebral metabolic rate of oxygen from the data of cerebral regional radioactivity collected after inhalation 0f15O2. A method was devised for the differential determination of the respective contribution of radiooxygen and of radiowater in the inflow and the outflow of radioactivity in the brain after or during such on inhalation. The results demonstrate the feasability of such a model and outline some of the methodological prerequisites to be taken into account in the numerical analysis of the data.",

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AU - Larson, K. B.

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AU - Ter-Pogossian, M. M.

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An introduction to the measurement of the cerebral oxygen uptake rate by inhalation of^l5o₂: Analysis of the contribution of^l5o₂ and h₂¹⁵o in brain radioactivity

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Keywords

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