An introduction to the measurement of the cerebral oxygen uptake rate by inhalation ofl5o2: Analysis of the contribution ofl5o2 and h215o in brain radioactivity

J. C. Depresseux, M. E. Raichle, K. B. Larson, J. Markham, M. M. Ter-Pogossian

Research output: Contribution to journalArticle

Abstract

This paper introduces a model for the computation of the regional cerebral metabolic rate of oxygen from the data of cerebral regional radioactivity collected after inhalation 0f15O2. A method was devised for the differential determination of the respective contribution of radiooxygen and of radiowater in the inflow and the outflow of radioactivity in the brain after or during such on inhalation. The results demonstrate the feasability of such a model and outline some of the methodological prerequisites to be taken into account in the numerical analysis of the data.

Original languageEnglish
Pages (from-to)207-214
Number of pages8
JournalEuropean neurology
Volume20
Issue number3
DOIs
StatePublished - Jan 1 1981

Keywords

  • BrainO
  • Model
  • Water metabolism

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