TY - JOUR
T1 - An introduction to recognizing functional domains
AU - Stormo, Gary D.
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2011/6
Y1 - 2011/6
N2 - This unit provides an overview of issues involved in domain recognition in protein and DNA sequences. It opens with a discussion of the two primary methods of domain representation, namely consensus sequences and alignment matrices (e.g., the log-odds matrix). The unit continues with a brief overview of some of the resources available for identifying functional domains in nucleotide sequences (e.g., transcription factor binding sites). In addition, it reviews databases such as Pfam and InterPro, which are available for protein analysis.
AB - This unit provides an overview of issues involved in domain recognition in protein and DNA sequences. It opens with a discussion of the two primary methods of domain representation, namely consensus sequences and alignment matrices (e.g., the log-odds matrix). The unit continues with a brief overview of some of the resources available for identifying functional domains in nucleotide sequences (e.g., transcription factor binding sites). In addition, it reviews databases such as Pfam and InterPro, which are available for protein analysis.
KW - Functional domains
KW - Promoters
KW - Protein domains
KW - Regulatory sites
KW - Transcription factor binding sites
UR - http://www.scopus.com/inward/record.url?scp=80051955648&partnerID=8YFLogxK
U2 - 10.1002/0471250953.bi0201s34
DO - 10.1002/0471250953.bi0201s34
M3 - Article
C2 - 21633944
AN - SCOPUS:80051955648
SP - 1
EP - 6
JO - Current protocols in bioinformatics / editoral board, Andreas D. Baxevanis ... [et al.]
JF - Current protocols in bioinformatics / editoral board, Andreas D. Baxevanis ... [et al.]
SN - 1934-3396
IS - SUPPL. 34
ER -