In bacteria, animals, fungi, and many single celled eukaryotes, division is initiated by the formation of a ring of cytoskeletal protein at the nascent division site. In bacteria, the tubulin-like GTPase FtsZ serves as the foundation for the cytokinetic ring. A conserved feature of FtsZ is an intrinsically disordered peptide known as the C-terminal linker. Chimeric experiments suggest the linker acts as a flexible boom allowing FtsZ to associate with the membrane through a conserved C-terminal domain and also modulates interactions both between FtsZ subunits and between FtsZ and modulatory proteins in the cytoplasm.

Original languageEnglish
Pages (from-to)3-10
Number of pages8
JournalSeminars in Cell and Developmental Biology
StatePublished - Jan 1 2015


  • Bacteria
  • Cell division
  • Cooperative assembly
  • Cytokinetic ring
  • FtsZ
  • Intrinsically disordered peptide


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