@inproceedings{6c1291399e1f4c01ab643af30e492f7d,
title = "An intraoperative probe combining positron detection and OCT imaging for ovarian cancer detection and characterization",
abstract = "In this paper, we report an intraoperative approach by combining optical coherence tomography (OCT) and position detection to detect and characterize ovarian cancers. A total of 18 ovaries were studied ex vivo. Based on histopathology result, they were classified into normal and malignant groups, respectively. On average positron count rate of 8.0-fold higher was found between malignant and normal ovaries. OCT imaging of ovaries revealed many detailed morphologic features that could be potentially valuable for detecting early malignant changes in ovarian tissue. Optical scattering coefficients of these ovaries were estimated from OCT A-lines. Normal ovarian tissue showed higher scattering coefficient than that of malignant ovarian tissue. Using a threshold of 2.00 mm -1 for all ovaries, a sensitivity of 100\% and a specificity of 100\% were achieved. This initial data shows our intraoperative probe based on OCT and positron detection has a great potential for ovarian cancer detection and characterization.",
keywords = "gynecology, intraoperative probe, optical coherence tomography, ovarian cancer, positron detection, scattering coefficient",
author = "Yi Yang and Tianheng Wang and Nrusingh Biswal and Patrick Kumavor and Xiaohong Wang and Mozafareddin Karimeddini and John Vento and Melinda Sanders and Molly Brewer and Quing Zhu",
year = "2012",
doi = "10.1117/12.907023",
language = "English",
isbn = "9780819488633",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Optical Biopsy X",
note = "Optical Biopsy X ; Conference date: 24-01-2012 Through 25-01-2012",
}